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首页> 外文期刊>Circulation journal >Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease
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Characteristics of Transient Receptor Potential Canonical Calcium-Permeable Channels and Their Relevance to Vascular Physiology and Disease

机译：瞬态受体潜在的规范钙渗透通道的特征及其与血管生理和疾病的关系。

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Transient receptor potential canonical (TRPC) proteins assemble to form ion channels that enable influx of calcium and sodium ions into cells. There are 6 TRPC proteins in humans but more TRPC channels may arise through heteromerization among TRPCs and other types of TRP protein. They are widely expressed and have multiple functions throughout the peripheral and central systems of the body. This review summarizes current knowledge of the characteristics of TRPC channels and discusses principles by which the channels operate. Modulators of the channels include lipids, redox factors, and agonists at G-protein and tyrosine kinase receptors. The channels enable coupling between these factors and the calcium ion, which is a master intracellular regulator of multiple cell functions. In the context of this information the review gives specific consideration to TRPC channels in vascular cells, which include endothelial cells, vascular smooth muscle cells, perivascular adipocytes, and cells of the hematopoietic lineage. It is discussed that the channels may have most significance as drivers of change when there is strain or insult in physiology or disease. The TRPC proteins constitute a substantial and important group of calcium-permeable channels. They remain enigmatic but there is increasing understanding of their properties and recognition of their importance in the vasculature as well as in other systems such as the myocardium.??( Circ J ?2013; 77 : 570–579)
机译：瞬时受体电位规范（TRPC）蛋白组装形成离子通道，使钙离子和钠离子流入细胞。人类中有6种TRPC蛋白，但通过TRPC与其他类型的TRP蛋白之间的异聚可能会产生更多的TRPC通道。它们被广泛表达并在人体的外围和中央系统中具有多种功能。这篇综述总结了有关TRPC通道特性的当前知识，并讨论了通道操作的原理。通道的调节剂包括脂质，氧化还原因子以及G蛋白和酪氨酸激酶受体的激动剂。这些通道可实现这些因子与钙离子之间的偶联，而钙离子是多种细胞功能的主要细胞内调节剂。在此信息的背景下，本综述特别考虑了血管细胞中的TRPC通道，包括内皮细胞，血管平滑肌细胞，血管周围脂肪细胞和造血谱系细胞。讨论了当生理或疾病受到压力或侮辱时，渠道作为改变的驱动因素可能具有最重要的意义。 TRPC蛋白构成钙渗透通道的重要组成部分。它们仍然是令人迷惑的，但是对它们的特性越来越了解，并且越来越认识到它们在脉管系统以及在心肌等其他系统中的重要性。（Circ J，2013; 77：570-579）

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