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首页> 外文期刊>Circulation journal >Sleep-Disordered Breathing Increases Risk for Fatal Ventricular Arrhythmias in Patients With Chronic Heart Failure
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Sleep-Disordered Breathing Increases Risk for Fatal Ventricular Arrhythmias in Patients With Chronic Heart Failure

机译：睡眠障碍性呼吸增加了慢性心力衰竭患者致命性室性心律失常的风险

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Background: ?It has been shown that sleep-disordered breathing (SDB) is associated with adverse prognosis in patients with chronic heart failure (CHF), but little is known about the relationship between SDB and life-threatening arrhythmias. Methods and Results: ?Fifty patients with CHF and SDB (33 male; mean age, 61 years) underwent Holter electrocardiogram and portable sleep monitoring simultaneously. The circadian variation in positive T-wave alternans (TWA; >65μV) was determined during 6-h intervals (0–6, 6–12, 12–18, and 18–24h). In addition, power spectral analysis of heart rate variability (HRV) was evaluated across a 24-h period. The subjects were divided into 2 groups based on whether respiratory disturbance index was ≥20events/h (Group A, n=24) or not (Group B, n=26). The prevalence of positive TWA, parameters in HRV and the occurrence of ventricular tachycardia (>5 beats) were compared between the 2 groups. The prevalence of positive TWA in Group A was significantly higher than that in Group B in all 6-h intervals. Low-frequency and high-frequency powers of HRV were significantly lower in Group A than in Group B across a 24-h period. Importantly, the prevalence of ventricular tachycardia was significantly higher in Group A than in Group B (46% vs. 19%, P=0.04). Conclusions: ?SDB may induce cardiac electrical instability associated with life-threatening arrhythmias across a 24-h period in CHF.??(Circ J?2013; 77: 1466–1473)
机译：背景：研究表明，睡眠呼吸障碍（SDB）与慢性心力衰竭（CHF）患者的不良预后相关，但对SDB与威胁生命的心律不齐之间的关系知之甚少。方法和结果：50例CHF和SDB患者（男33例，平均年龄61岁）同时接受动态心电图和便携式睡眠监测。在6小时间隔（0-6、6-12、12-18和18-24h）内确定正T波交替蛋白（TWA;>65μV）的昼夜节律变化。此外，在24小时内评估了心率变异性（HRV）的功率谱分析。根据呼吸障碍指数是否≥20events / h（A组，n = 24）（B组，n = 26）将受试者分为2组。比较两组的TWA阳性率，HRV参数和室性心动过速的发生（> 5次）。在所有6小时间隔内，A组的TWA阳性患病率均显着高于B组。在24小时内，A组的HRV低频和高频功率显着低于B组。重要的是，A组的室性心动过速的发生率显着高于B组（46％对19％，P = 0.04）。结论：？SDB可能在24小时内导致CHF危及生命危险的心律失常相关的心脏电不稳定。（Circ J？2013; 77：1466-1473）

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