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首页> 外文期刊>Circulation journal >Low High-Density Lipoprotein Cholesterol and Low/Normal Body Mass Index Are Associated With Increased Mortality in Coronary Artery Disease Patients in Taiwan
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Low High-Density Lipoprotein Cholesterol and Low/Normal Body Mass Index Are Associated With Increased Mortality in Coronary Artery Disease Patients in Taiwan

机译：低密度高脂蛋白胆固醇和低/正常体重指数与台湾冠状动脉疾病患者的死亡率增加相关

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Background: ?Among patients with coronary artery disease (CAD), high-density lipoprotein cholesterol (HDL-C) is a cardiac protective factor. In contrast, body mass index (BMI) is inversely related to mortality, and this is known as the obesity-mortality paradox. The relationship of HDL-C and BMI to mortality, however, has not been clarified well. The aim of this study was to evaluate the impact of HDL-C and BMI on mortality among CAD patients. Methods and Results: ?A cohort of 1,114 angiographic CAD patients from the ET-CHD registry during 1997–2003 in Taiwan was studied. The subjects were categorized into 4 groups according to BMI ≥25kg/m2 (overweight/obese) or BMI 2 (normal/underweight), and HDL-C higher or lower than the median of 40mg/dl in men and 45mg/dl in women. At a mean follow-up of 5.3 years, cardiac and all-cause death were the primary endpoints. On multivariate analysis, low HDL-C predicted higher cardiac and all-cause mortality in normal/underweight patients (hazard ratio [HR], 1.59; 95% confidence interval [CI]: 1.08–2.33; and 1.65, 95% CI: 1.25–2.19, respectively). In contrast, high BMI predicted lower cardiac and all-cause mortality in patients with low HDL-C (HR, 0.78; 95% CI: 0.54–1.14; and 0.66, 95% CI: 0.49–0.88, respectively). Conclusions: ?Among CAD patients in Taiwan, those with low HDL-C and normal/underweight had higher risk of mortality.??( Circ J ?2013; 77: 2079–2087)
机译：背景：在冠心病（CAD）患者中，高密度脂蛋白胆固醇（HDL-C）是心脏保护因子。相反，体重指数（BMI）与死亡率成反比，这被称为肥胖与死亡率的悖论。然而，HDL-C和BMI与死亡率之间的关系还不清楚。这项研究的目的是评估HDL-C和BMI对CAD患者死亡率的影响。方法和结果：研究了台湾地区1997-2003年来自ET-CHD登记处的1114例血管造影CAD患者。根据BMI≥25kg/ m 2 （超重/肥胖）或BMI 2 （正常/体重不足）以及HDL-C高于或低于中位数，将受试者分为4组。男性为40mg / dl，女性为45mg / dl。平均随访5.3年，心源性和全因死亡是主要终点。在多因素分析中，低HDL-C预测正常/体重不足患者的心脏和全因死亡率较高（危险比[HR]为1.59; 95％置信区间[CI]：1.08–2.33; 1.65，95％CI为1.25） –2.19）。相反，高BMI预测低HDL-C患者的心脏和全因死亡率较低（HR，0.78; 95％CI：0.54-1.14; 0.66，95％CI：0.49-0.88）。结论：台湾地区的CAD患者中，HDL-C低且体重正常/体重不足的患者死亡风险更高。（Circ J，2013; 77：2079-2087）

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