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首页> 外文期刊>Circulation journal >Negative Impact of Cardiovascular Risk Factors on Left Atrial and Left Ventricular Function Related to Aortic Stiffness – New Application of 2-Dimensional Speckle-Tracking Echocardiography –
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Negative Impact of Cardiovascular Risk Factors on Left Atrial and Left Ventricular Function Related to Aortic Stiffness – New Application of 2-Dimensional Speckle-Tracking Echocardiography –

机译：心血管危险因素对与主动脉僵硬相关的左心房和左心室功能的负面影响–二维斑点跟踪超声心动图的新应用–

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Background: ?The aim of the present study was to detect earlier the negative effect of cardiovascular risk (CVR) factors on left atrial (LA) and left ventricular (LV) function related to abdominal aortic (AAO) stiffness using 2-dimensional speckle-tracking echocardiography (2DSTE) in asymptomatic patients. Methods and Results: ?One hundred and twelve patients with CVR factors and 56 healthy individuals were studied. 2DSTE data were acquired for determination of LA and LV myocardial and AAO wall deformations. LA volume index, LV mass index, ratio of early diastolic transmitral flow to mitral annular velocity (E/e’)/peak systolic LA strain (S-LAs), and AAO stiffness were greater, and peak early diastolic LV longitudinal strain rate (SR-LVe) was lower in the patient group. Among the significantly correlated variables with AAO stiffness on univariate analysis, multivariate linear regression analysis identified SR-LVe and (E/e’)/S-LAs in the patient group, and only age in the healthy group, as independent predictor of AAO stiffness. Conclusions: ?Structural and functional changes in the LA and LV and AAO stiffening were accelerated with CVR factors, and higher AAO stiffness was associated with deteriorated LA compliance and impaired LV relaxation in asymptomatic patients with CVR factors. 2DSTE has a potential for earlier detection of abnormal LA and LV function related to increased AAO stiffness.??(Circ J?2013; 77: 1490–1498)
机译：背景：本研究的目的是使用二维散斑散斑技术，尽早发现心血管风险（CVR）因素对与腹主动脉（AAO）僵硬相关的左心房（LA）和左心室（LV）功能的负面影响。追踪无症状患者的超声心动图（2DSTE）。方法和结果：研究了112名CVR因素患者和56名健康个体。获取2DSTE数据以确定LA和LV心肌以及AAO壁的变形。 LA体积指数，LV质量指数，早期舒张传递流量与二尖瓣环速度（E / e'）/峰值收缩期LA应变（S-LAs）的比值和AAO刚度均较大，并且舒张早期LV纵向峰值应变率最高（ SR-LVe）在患者组中较低。在单变量分析中与AAO刚度显着相关的变量中，多元线性回归分析确定了患者组中SR-LVe和（E / e'）/ S-LAs，而健康组中只有年龄是AAO刚度的独立预测因子。结论：CVR因子可加速LA和LV的结构和功能变化以及AAO的硬化，而无症状CVR因子患者的AAO刚性更高与LA顺应性恶化和LV松弛受损有关。 2DSTE有可能更早地发现与AAO刚度增加有关的异常LA和LV功能。（Circ J？2013; 77：1490-1498）

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