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首页> 外文期刊>Circulation journal >Amniotic Fluid Natriuretic Peptide Levels in Fetuses With Congenital Heart Defects or Arrhythmias
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Amniotic Fluid Natriuretic Peptide Levels in Fetuses With Congenital Heart Defects or Arrhythmias

机译：先天性心脏缺陷或心律不齐的胎儿羊水利钠肽水平

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Background: We have previously demonstrated that umbilical cord plasma natriuretic peptide (NP) levels reflect the severity of heart failure (HF) in fetuses with congenital heart defects (CHD). The aim of this study was to evaluate the significance of amniotic fluid (AF) NP levels in the assessment of HF in fetuses with CHD or arrhythmia. Methods?and?Results: This was a prospective observational study at a tertiary pediatric cardiac center. A total of 95 singletons with CHD or arrhythmia, and 96 controls from 2012 to 2015 were analyzed. AF concentrations of atrial NP (ANP), B-type NP (BNP) and N-terminal pro-B-type NP (NT-proBNP) at birth were compared with ultrasonographic assessment of fetal HF using the cardiovascular profile (CVP) score. Multivariate analysis showed that a CVP score ≤5 and preterm birth are independently associated with high AF NT-proBNP levels. AF NT-proBNP levels of fetuses with CHD or arrhythmia inversely correlated with CVP score (P for trend Conclusions: AF NT-proBNP concentrations increase in stepwise fashion with the severity of HF in fetuses with CHD or arrhythmia; it was the optimal NP for assessing the fetal HF.
机译：背景：我们以前已经证明，脐带血浆利钠肽（NP）的水平反映了患有先天性心脏缺陷（CHD）的胎儿的心力衰竭（HF）的严重程度。这项研究的目的是评估羊水（AF）NP水平在评估CHD或心律不齐的胎儿的HF中的意义。方法和结果：这是在三级儿科心脏中心进行的一项前瞻性观察性研究。分析2012年至2015年共95例患有CHD或心律失常的单身人士和96例对照。使用心血管特征（CVP）评分，比较出生时房性NP（ANP），B型NP（BNP）和N端pro-B型NP（NT-proBNP）的AF浓度与胎儿HF的超声检查。多因素分析表明，CVP评分≤5和早产与AF NT-proBNP水平高相关。患有冠心病或心律不齐的胎儿的AF NT-proBNP水平与CVP评分呈负相关（趋势的结论为P：随冠心病或心律不齐的胎儿的HF严重程度，AF NT-proBNP浓度呈逐步增加的趋势;这是评估的最佳NP胎儿HF。

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