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首页> 外文期刊>Circulation journal >Asymmetric Dimethylarginine Attenuates the Association of Melatonin Secretion With Night-Time Blood Pressure and Dipping in Elderly Individuals – The HEIJO-KYO Cohort –
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Asymmetric Dimethylarginine Attenuates the Association of Melatonin Secretion With Night-Time Blood Pressure and Dipping in Elderly Individuals – The HEIJO-KYO Cohort –

机译：HEIJO-KYO队列研究显示，不对称的二甲基精氨酸可减轻褪黑激素分泌与夜间血压和老年人浸出的关系。

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Background: Melatonin decreases night-time blood pressure (BP) by increasing nitric oxide (NO) in endothelial cells. Whether serum asymmetric dimethylarginine (ADMA), a major endogenous competitive inhibitor of endothelial NO synthase, attenuates the association of melatonin with night-time BP and dipping in humans is unclear. Methods?and?Results: In this cross-sectional study of 852 community-based elderly individuals, serum ADMA, overnight urinary 6-sulfatoxymelatonin excretion (UME), and ambulatory BP were measured. Mean ADMA was 0.46±0.06 μmol/L. In the low-ADMA group (n=451), crude OR for nocturnal hypertension (NH) and non-dipper significantly decreased with a quartile increase in UME (P=0.023 and 0.001, respectively), but these associations were not observed in the high-ADMA group (n=401). Higher UME was significantly and inversely associated with adjusted OR for NH and non-dipper in the low-ADMA group (Q1, 1.00 and 1.00; Q2, 0.92 and 0.74; Q3, 0.57 and 0.51; Q4, 0.48 and 0.40; P=0.004 and 0.002, respectively) but not in the high-ADMA group (P=0.75 and 0.12, respectively). These association trends were also observed on continuous variable analysis (low ADMA, P=0.031 and 0.003; high ADMA, P=0.52 and 0.13; respectively). Conclusions: ADMA attenuates the association of endogenous melatonin with night-time BP and dipping in the general elderly population. ( Circ J 2014; 78: 2908–2914)
机译：背景：褪黑激素通过增加内皮细胞中的一氧化氮（NO）降低夜间血压（BP）。尚不清楚血清不对称二甲基精氨酸（ADMA）是内皮细胞NO合酶的主要内源性竞争抑制剂，是否能减弱褪黑素与夜间BP的关联以及在人体内浸入。方法和结果：在本项针对852名社区老年人的横断面研究中，测量了血清ADMA，过夜尿液中的6-硫氧嘧啶褪黑激素排泄（UME）和动态血压。平均ADMA为0.46±0.06μmol/ L。在低ADMA组（n = 451）中，夜间高血压（NH）和非北斗星的粗OR随UME的四分位数增加而显着降低（分别为P = 0.023和0.001），但是在ADMA组中未观察到这些关联高ADMA组（n = 401）。在低ADMA组中，较高的UME与调整后的NH和非北斗星OR显着且呈负相关（Q1，1.00和1.00; Q2，0.92和0.74; Q3，0.57和0.51; Q4，0.48和0.40; P = 0.004和分别为0.002和0.002），但不在高ADMA组中（分别为P = 0.75和0.12）。在连续变量分析中也观察到了这些关联趋势（低ADMA，P = 0.031和0.003;高ADMA，P = 0.52和0.13;）。结论：ADMA减弱了普通老年人中内源性褪黑素与夜间BP和浸入的关系。 （Circ J 2014; 78：2908–2914）

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