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首页> 外文期刊>Case Reports in Obstetrics and Gynecology >A Rare Presentation of Stage IV Large Cell Neuroendocrine Carcinoma of the Cervix with Metastasis to the Cranium
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A Rare Presentation of Stage IV Large Cell Neuroendocrine Carcinoma of the Cervix with Metastasis to the Cranium

机译：宫颈Ⅳ期大细胞神经内分泌癌的罕见表现，转移至颅骨

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Neuroendocrine tumors (NETs) are aggressive diseases developing from neuroendocrine cells that most frequently involve the gastro-entero-pancreatic tract and the lung, but more rarely are found in almost all body tissues. Limited biological and clinical data are currently available for NETs in uncommon sites, such as female genital tract. NETs represent 0.9% to 1.5% of the tumors of the uterine cervix. This case is reported on a 75-year-old Caucasian woman, presenting with dental and generalized pain for two weeks. Later during her admission, facial droop and diplopia were noticed. Radiological findings ruled out cerebrovascular accident but revealed multiple bone marrow lesions involving the left and the right clivus, right Meckel's cave, and posterior margin of the right cavernous sinus. Findings also included pulmonary nodules and adenopathy supporting diagnosis of likely stage IV metastatic carcinoma. Further imaging revealed homogeneous enhancement of the uterus suggestive of diffusely infiltrative carcinoma; pathology results confirmed large cell neuroendocrine carcinoma of the uterine cervix (LCNEC) giving her a 1.5-month median survival range.
机译：神经内分泌肿瘤（NETs）是由神经内分泌细胞发展而来的侵袭性疾病，其中神经内分泌细胞最常涉及胃肠-胰腺和肺部，但几乎在所有人体组织中都很少见。目前，在女性生殖道等罕见部位，NETs的生物学和临床数据有限。 NET占子宫颈肿瘤的0.9％至1.5％。该病例报告于一名75岁的白人妇女，患有牙齿和全身性疼痛两周。在她入院的后期，发现面部下垂和复视。影像学检查结果排除了脑血管意外，但显示出多发性骨髓病变，涉及左，右锁骨，右Meckel's洞穴和右海绵窦的后缘。研究结果还包括肺结节和腺病，支持诊断可能的IV期转移性癌。进一步的影像学检查提示子宫均匀增生，提示弥漫性浸润癌。病理结果证实宫颈大细胞神经内分泌癌（LCNEC）使她的中位生存期为1.5个月。

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