...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical Cancer Investigation Journal >Follicular dendritic cell sarcoma of the tonsil: A rare entity
【24h】

Follicular dendritic cell sarcoma of the tonsil: A rare entity

机译：扁桃体的滤泡性树突状细胞肉瘤：一种罕见的实体

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Follicular dendritic cells (FDC) are nonlymphoid, nonphagocytic accessory cells in the immune system. They have major roles in antigen presentation and regulation of germinal center reaction. FDC sarcoma is a rare and under-recognized malignancy. Most of the cases are reported in the lymph nodes. The typical morphology is syncytial aggregates of oval/spindly cells with vesicular bland nuclei and small nucleoli. Focal whorling and storiform pattern, multinucleate giant cells, and the presence of small lymphocytes in the background give additional clues for the diagnosis. As spindle cell tumors are rare in the lymph nodes, FDC sarcoma comes under the differential diagnosis of spindle cell neoplasms of the node and an accurate diagnosis is often rendered. However, when the neoplasm occurs in extranodal sites, the diagnosis is often missed because the FDC markers are not routinely used in the immunopanel for undifferentiated neoplasms. Because of its rarity, the extranodal FDC sarcomas pose a great diagnostic challenge and often misdiagnosed initially. Herein, we report a case of FDC sarcoma of the tonsil in a 36-year-old female patient. Biopsy of the lesion showed oval to spindly cells in syncytial sheets and focally in whorled pattern. The individual cells were having plump vesicular nuclei and small nucleoli. Occasional multinucleate cells and sprinkling of lymphocytes within the tumor were also noted. The tumor cells were positive for CD23 and CD35. A diagnosis of FDC sarcoma was given. Greater awareness of the morphologic spectrum of FDC sarcoma and appropriate immunostains for FDC differentiation will help in recognition of this rare neoplasm.
机译：滤泡树突状细胞（FDC）是免疫系统中的非淋巴，非吞噬性辅助细胞。它们在抗原呈递和生发中心反应的调节中起主要作用。 FDC肉瘤是一种罕见且认识不到的恶性肿瘤。多数病例报告于淋巴结。典型的形态是卵圆形/散在的细胞的合胞体聚集体，具有囊泡性腺核和小核仁。局灶性轮状和星形状模式，多核巨细胞以及背景中小淋巴细胞的存在为诊断提供了其他线索。由于纺锤状细胞瘤在淋巴结中很少见，因此FDC肉瘤受到淋巴结纺锤状细胞瘤的鉴别诊断，因此常常可以做出准确的诊断。但是，当肿瘤发生在结外部位时，由于未分化肿瘤的免疫板中常规不使用FDC标记，因此常常会漏诊。由于它的稀有性，结外FDC肉瘤构成了巨大的诊断挑战，并且通常在最初被误诊。在此，我们报告了一名36岁女性患者的扁桃体FDC肉瘤。病变活检显示卵圆形到棘突状细胞呈合胞体片状，并呈螺旋状。单个细胞具有丰满的水泡核和小的核仁。还注意到偶发性多核细胞和肿瘤内淋巴细胞的散落。肿瘤细胞对CD23和CD35呈阳性。诊断为FDC肉瘤。对FDC肉瘤的形态学谱的更多了解以及用于FDC分化的​​适当免疫染色将有助于识别这种罕见肿瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号