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首页> 外文期刊>Clinical and Translational Allergy >Colloidal silica-induced hypersensitivity: myth or reality topics: clinical cases/case series: non-immediate elayed T cells IgG
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Colloidal silica-induced hypersensitivity: myth or reality topics: clinical cases/case series: non-immediate elayed T cells IgG

机译：胶体二氧化硅引起的超敏反应：神话或现实主题：临床病例/病例系列：非立即洗脱的T细胞IgG

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BackgroundColloidal silica is an inorganic substance widely used asexcipient in pharmaceutical preparation. It acts as a vehiculeto increase the absorption of many oral drug formulations.Many excipients have been reported to induce drughypersensitivity such as tartrazine, aspartame, benzalkoniumchloride, sodium metabisulphite, propyl gallate.However, colloidal silica has never been reported toinduce hypersensitivity. We report herein a case of colloidalsilica-induced hypersensitivity confirmed by a positivepatch test.Case reportA 40-year-old patient was prescribed diclofenac (Voltarene? 50 mg enteric coated tablet, Novartis) for a rightgoneitis. On the second day of treatment, he presented ageneralized maculo-papular eruption with neither fevernor lymph node swelling. Laboratory findings showedeosinophilia (500 cells/μL) with normal hepatic and renalfunction. Voltarene? was discontinued and the symptomshad resolved one week later. One month after totalrecovery, a patch test to diclofenac (Voltarene?, 50 mgenteric coated tablet, Novartis) was performed on theback of the patient, and was positive. In order to investigatecross reactivity, we performed a patch test to othernon steroidal anti-inflammatory drugs (NSAID), i.e; piroxicam(Piroxen?), ketoprofen (Oki?), indometacine(Indocid?), tiaprofenic acid (Surgam?), acetyl salicylicacid (Aspegic?). These tests were positives only for piroxicam,ketoprofen and indometacine. When examiningdifferent NSAID formulations used in patch testing, wefound that colloidal silica was present in tablets of voltanene?, Piroxen?, Oki?, Indocid? and was absent inSurgam? and Aspegic?. So that, a patch test to colloidalsilica was performed (10% in petrolatum) and was positiveat 48h reading. A control patch test was conductedin three healthy controls following to the same procedureand was negative in all of them.ConclusionTo the best of our knowledge, this case is the first todescribe a skin hypersensitivity induced by colloidalsilica confirmed by a positive patch test.
机译：背景技术胶体二氧化硅是在药物制备中广泛用作赋形剂的无机物质。它可作为增加许多口服药物制剂吸收的媒介物。据报道，许多赋形剂会引起药物超敏反应，例如酒石黄，阿斯巴甜，苯扎氯铵，偏亚硫酸氢钠，没食子酸丙酯，但从未报道过胶体二氧化硅会引起超敏反应。我们在此报告了一种由阳性贴片试验证实的胶体二氧化硅诱发的超敏反应的病例。病例报告一名40岁的患者因右胸炎开了双氯芬酸（Voltarene？50 mg肠溶片，Novartis）。在治疗的第二天，他出现了泛斑性黄斑丘疹，既没有发烧也没有淋巴结肿胀。实验室检查发现嗜酸性粒细胞增多症（500个细胞/μL）具有正常的肝和肾功能。 tar烯已停药，一周后症状已缓解。全部恢复后一个月，在患者的背部进行了双氯芬酸（Voltarene？，50 mgenteric包衣的片剂，诺华公司）的贴剂测试，呈阳性。为了研究交叉反应性，我们对其他非甾体类抗炎药（NSAID）进行了补丁测试，即吡罗昔康（Piroxen？），酮洛芬（Oki？），吲哚美辛（Indocid？），噻洛芬酸（Surgam？），乙酰水杨酸（Aspegic？）。这些测试仅对吡罗昔康，酮洛芬和吲哚美辛为阳性。在检查用于贴剂测试的不同NSAID制剂时，我们发现，在Voltanene？，Piroxen？，Oki？，Indocid？并在苏加姆缺席吗？和Aspegic？因此，对胶体二氧化硅进行了贴片测试（凡士林中的含量为10％），并且在48h读数时呈阳性。对三个健康对照者进行相同步骤的对照贴剂试验，所有试验均为阴性。结论据我们所知，本例是第一个描述由阳性贴剂试验证实的由胶体二氧化硅引起的皮肤超敏反应的病例。

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