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首页> 外文期刊>Clinical and Translational Allergy >Usefulness of patch tests in drug adverse reaction induced by tetrazepam and anti-inflammatory drugs
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Usefulness of patch tests in drug adverse reaction induced by tetrazepam and anti-inflammatory drugs

机译：斑贴试验在四西p和抗炎药引起的药物不良反应中的作用

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Skin testing with the suspected drugs may be helpful indetermining the cause of a cutaneous adverse reaction(CADR). Tetrazepam (T) is a muscle relaxant of the benzodiazepinegroup frequently used in rheumatology inassociation with anti-inflammatory drugs (AIDs). Wepropose to determine the usefulness of patch testing inthis context. Patients and methods A retrospective studywas conducted including all patients referred between2000 and 2010 for patch testing after a CADR occurringafter concomitant administration of T and AIDs. Patchtest were performed at least 6 weeks after healing with Tand AIDs diluted at 10 % in petrolatum in a commercialform (Chemotechnique Laboratory Diagnostics, Malm?,Sweden) or crushed and diluted in petroleum. Allpatients were contacted by letter in 2010 and data concerningT or AID rechallenge, after the patch testing,were collected. T patch testing was also performed on 10controls, ie individuals who already took T but did notpresent any CADR.Results15 subjects with a past history of CADR were referred forpatch testing with both T and AIDs possible / probableculprit drugs. Among this patients, CADR included StevensJohnson/toxic epidermal necrolysis (5), maculopapularrash (7), Drug Reaction with Eosinophilia and SystemicSymptoms (1) and Acute Generalized Exanthematous Pustulosis(2). AIDs included ketoprofene (3), diclofenac (2),rofecoxib (2), piroxicam (5), naproxène (1), prednisone (1),cortivazol (1). Patch tests were positive for T and negativefor AIDs in 80 % of cases (12). Both patch tests werenegative in 20% (3). All the 10 control subjects hadnegative patch test to T. Nine subjects answered to ourletter, none of them has been rechallenged with either Tor AIDs, whatever the results of the tests. Comments PositiveT patch tests were obtained in 80% of cases whateverthe CARDs. This was much higher than the usual 30-50%rate observed in the literature with miscellaneous drugs.All the T exposed control subjects were negative as were100 non exposed controls reported in literature. However,its predictive value can not be determined in absence ofrechallenge after negative patch test. T CADR may be systematicallysuspected even in case of concomitant AIDsintake. Readministration of AID could be allowed in nonsevere CADR with negative AID patch testing and positiveone for T.
机译：用可疑药物进行皮肤测试可能有助于确定皮肤不良反应（CADR）的原因。 Tetrazepam（T）是苯二氮卓类的肌肉松弛剂，常用于风湿病学与抗炎药（AIDs）联合使用。我们建议确定在这种情况下补丁测试的有用性。患者和方法进行了一项回顾性研究，其中包括2000年至2010年之间在同时施用T和AID后发生CADR后转诊的所有患者。愈合后至少6周进行贴片测试，其中的Tand AID以市售形式（凡士林，Chemotechnique Laboratory Diagnostics，瑞典，马尔默）稀释或在石油中稀释，稀释至10％的凡士林稀释。在2010年通过信函与所有患者进行了联系，并在贴片测试后收集了有关T或AID再挑战的数据。还对10个对照（即已经服用过T但未表现出任何CADR的个体）进行了T斑测试。结果将15名具有CADR历史的受试者转诊进行T斑测试，同时使用T和AID可能/可能的罪魁祸首药物。在这些患者中，CADR包括StevensJohnson /毒性表皮坏死溶解（5），斑丘疹（7），与嗜酸性粒细胞增多症和全身症状的药物反应（1）和急性泛发性脓疱病（2）。艾滋病包括酮乙（3），双氯芬酸（2），罗非昔布（2），吡罗昔康（5），萘普生（1），泼尼松（1），Cortivazol（1）。在80％的病例中，贴片检测的T阳性，AID阴性（12）。两种补丁测试的阴性率为20％（3）。所有10位对照受试者对T均进行了阴性贴片测试。有9位受试者回答了我们的信，无论测试结果如何，都没有接受过Tor AID的挑战。注释在80％的情况下，无论使用哪种CARD，都获得了PositiveT补丁测试。这远高于文献中使用其他药物时通常观察到的30-50％的比率。所有T暴露对照受试者均为阴性，文献中报道的100个未暴露对照也是如此。但是，如果在阴性斑贴试验后没有挑战，则无法确定其预测值。即使同时摄入AID，也可能会系统地怀疑T CADR。在非严重CADR中，如果AID斑贴试验为阴性而T为正值，则可以允许AID的重新分配。

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