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Comparison of three criteria for potentially inappropriate medications in Chinese older adults

机译：中国老年人潜在不适当用药的三种标准的比较

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Objectives: This study aimed to compare the prevalence of potentially inappropriate medications (PIMs) among Chinese aged patients using the Beers criteria of 2015, the Screening Tool of Older Persons’ Prescriptions (STOPP) of 2014 and the criteria of PIMs for older adults in China (Chinese criteria), and to identify the correlates of the PIMs’ use. Methods: A retrospective, cross-sectional study was conducted among geriatric patients at Beijing Chao-Yang Hospital between January 2018 and March 2018. Three criteria (the Beers criteria of 2015, the STOPP criteria of 2014 and the Chinese criteria) were used to detect PIMs. A multivariate logistic regression analysis was carried out to determine factors associated with the use of PIMs. Leading PIMs for each set of criteria were also listed. The concordance among the three PIM criteria was calculated using kappa tests. Results: Totally, 863 inpatients aged ≥65 years were included. The prevalence of patients receiving at least one PIM was 80.2%, 58.1% and 44.0% according to the Chinese criteria, 2015 Beers criteria and 2014 STOPP criteria, respectively. The Beers and the STOPP criteria indicated a moderate coherence, whereas the Chinese criteria showed poor concordance with the other two criteria. Proton-pump inhibitors in the Beers and STOPP criteria and clopidogrel in the PIM-Chinese accounted for most leading PIMs. The most important factor associated with PIM use by all three sets of criteria was the number of prescribed medications. Conclusion: Data showed a high PIM prevalence among older adults in China, which was associated with the number of prescribed medications. The Chinese criteria had the highest detection rate but a poor concordance with the Beers and STOPP criteria ( P 0.001).
机译：目的：本研究旨在比较2015年比尔斯标准，2014年老年人处方筛选工具（STOPP）和中国老年人PIM标准在中国老年患者中潜在不适当用药（PIM）的发生率。 （中国标准），并确定PIM使用的相关性。方法：回顾性，横断面研究于2018年1月至2018年3月在北京朝阳医院老年患者中进行。采用三个标准（2015年的比尔斯标准，2014年的STOPP标准和中国标准）进行检测PIM。进行了多元logistic回归分析，以确定与使用PIM相关的因素。还列出了每套标准的领先PIM。使用kappa测试计算了三个PIM标准之间的一致性。结果：总共纳入了863位≥65岁的住院患者。根据中国标准，2015 Beers标准和2014 STOPP标准，接受至少一种PIM的患者患病率分别为80.2％，58.1％和44.0％。 Beers和STOPP标准显示出适度的连贯性，而中文标准显示与其他两个标准的一致性差。在Beers和STOPP标准中，质子泵抑制剂和中国PIM中的氯吡格雷占大多数领先的PIM。所有这三套标准中与PIM使用相关的最重要因素是处方药的数量。结论：数据显示，中国老年人中PIM患病率较高，这与处方药的数量有关。中国标准的检出率最高，但与Beers和STOPP标准的一致性差（P <0.001）。

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