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首页> 外文期刊>Clinical Interventions in Aging >Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
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Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials

机译：进行体育锻炼可以改善阿尔茨海默氏病患者的认知：随机对照试验的系统评价和荟萃分析

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Background/objective: Alzheimer’s disease (AD) is mainly characterized by decline of cognitive functions such as memory and learning, which has a high prevalence and poor drug efficacy in treatment regimes. A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to evaluate the effectiveness of exercise on cognitive function in patients diagnosed with AD. Methods: The bibliographic databases (PubMed, Cochrane Library and Embase, and Web of Science) and four Chinese databases (Wanfang data, CBM, CNKI, and VIP) were searched to identify RCTs published in any language between January 1, 1960, and January 1, 2018. Only peer-reviewed articles and RCTs were included. The collected data were analyzed by Review Manager (5.3). Results: Overall, 869 patients diagnosed with AD were included from 13 RCTs. Patients in the intervention group received pure exercise interventions and a cognitive test. Although there was heterogeneity in intervention methods and cognitive measures among studies, meta-analysis (seven studies) supports positive effects of physical activity on cognitive function of patients with AD (mean difference [MD]?=2.53, the 95% CI=0.84 to 4.22, test for overall effect: Z =2.93 [ P =0.003]). Eight studies demonstrated that exercise improves cognitive function for individuals with AD. However, the remaining five studies did not display a beneficial effect of exercise on cognitive function in patients with AD. Conclusion: This meta-analysis and systematic review indicated that exercise intervention might improve the cognitive function of AD or slow down the decline of cognition; however, this relationship was not always true across studies. RCTs with clear intervention criteria, large samples, and long-term follow-up are needed in the future to demonstrate the benefits of exercise for cognitive function in AD patients.
机译：背景/目的：阿尔茨海默氏病（AD）的主要特征是认知功能（例如记忆力和学习力）下降，在治疗方案中患病率高，药物疗效差。对随机对照试验（RCT）进行了系统的回顾和荟萃分析，以评估运动对诊断为AD的患者认知功能的有效性。方法：检索书目数据库（PubMed，Cochrane图书馆和Embase以及Web of Science）和四个中文数据库（Wanfang数据，CBM，CNKI和VIP），以识别1960年1月1日至1月之间以任何语言发布的RCT。 2018年1月1日。仅包括经过同行评审的文章和RCT。审核经理（5.3）对收集到的数据进行了分析。结果：总共从13个RCT中纳入869例被诊断为AD的患者。干预组的患者接受纯运动干预和认知测试。尽管研究之间的干预方法和认知措施存在异质性，但荟萃分析（七项研究）支持体育锻炼对AD患者认知功能的积极影响（平均差异[MD]？= 2.53，95％CI = 0.84）。 4.22，测试整体效果：Z = 2.93 [P = 0.003]。八项研究表明，运动可以改善AD患者的认知功能。但是，其余五项研究并未显示运动对AD患者认知功能的有益作用。结论：这项荟萃分析和系统评价表明，运动干预可能会改善AD的认知功能或减缓认知能力的下降。然而，这种关系在研究中并不总是正确的。将来需要具有明确干预标准，大量样本和长期随访的RCT，以证明运动对AD患者认知功能的益处。

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