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首页> 外文期刊>Clinical and Translational Allergy >HLA-B*15:02 genotype associated with hypersensitivity syndrome to lamotrigine in Thai population
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HLA-B*15:02 genotype associated with hypersensitivity syndrome to lamotrigine in Thai population

机译：HLA-B * 15：02基因型与泰国人群对拉莫三嗪过敏综合征相关

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BackgroundLamotrigine is a commonly used in psychiatric patients.The aims of this study were to determine the possibleassociations of lamotrigine-induced hypersensitivitysyndrome with the HLA-B alleles in Thai patients.HLA-B*58:01 allele was also observed in Han Chinesepatients with epilepsy and lamotrigine-induced SCARs(severe cutaneous adverse drug reactions).MethodA total of 133 patients, including 11 patients withlamotrigine-induced hypersensitivity syndrome (MPE;maculo-papular exanthema, SJS; Stevens-Johnsonsyndrome and TEN; toxic epidermal necrolysis),9 lamotrigine-tolerant controls and 113 healthy controlswere included in this study. HLA-B genotyping wasperformed. This case-control study was approved by theEthics Committee of Ramathibodi Hospital.ResultsHLA-B*15:02 allele was present in 27.3% (3/11) of Thaipatients with lamotrigine-induced hypersensitivity syndromebut in only 11.1% (1/9) of lamotrigine-tolerantcontrols and 13.2% of 113 healthy controls (P-value<0.05). Other HLA-B allele, including HLA-B*58:01 wasobserved in a case group.ConclusionOur results support the hypothesis that HLA-B*15:02contribute to the genetic susceptibility to lamotrigineinducedhypersensitivity syndrome and may be valuableas potential biomarkers for prediction lamotrigineinducedhypersensitivity syndrome in Thai population.A major limitation of this study was the size of the sampleavailable for the analysis. Confirmation of these results ina larger, independent sample is needed.
机译：背景拉莫三嗪是精神病患者中常用的一种药物，本研究旨在确定拉莫三嗪诱发的超敏综合征与泰国患者的HLA-B等位基因可能的关联.HLA-B * 58：01等位基因在中国汉族癫痫患者中也观察到方法共有133例患者，其中11例患有拉莫三嗪诱发的超敏反应综合征（MPE;马丘疹性皮疹，SJS; Stevens-Johnsonsyndrome和TEN;中毒性表皮坏死）; 9例拉莫三嗪耐受性对照和113例健康对照纳入本研究。进行HLA-B基因分型。该病例对照研究获得了拉马替博迪医院伦理委员会的批准。结果HLA-B * 15：02等位基因存在于27.3％（3/11）的拉莫三嗪诱发的超敏反应综合征的泰国患者中，但仅占11.1％（1/9）的泰国患者中拉莫三嗪耐受性对照和113个健康对照的13.2％（P值<0.05）。在病例组中观察到了其他HLA-B等位基因，包括HLA-B * 58：01。结论我们的结果支持以下假设：HLA-B * 15：02有助于拉莫三嗪诱发的超敏性综合征的遗传易感性，可能可作为预测拉莫三嗪诱发的超敏性综合征的潜在生物标志物这项研究的主要局限性是可用于分析的样本量。这些结果的确认需要一个更大的独立样本。

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