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首页> 外文期刊>Clinical and Translational Allergy >Comparison of atopy patch testing to skin prick testing for diagnosing mite-induced atopic dermatitis: a systematic review and meta-analysis
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Comparison of atopy patch testing to skin prick testing for diagnosing mite-induced atopic dermatitis: a systematic review and meta-analysis

机译：特应性斑贴试验与皮肤点刺试验在螨虫诱发的特应性皮炎诊断中的比较：系统评价和荟萃分析

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Atopic dermatitis (AD) can occur after contact with aeroallergens like house dust mites, pollen, and animal dander. Despite its controversial diagnostic value, the atopy patch test (APT) has been used as an important tool in the diagnosis of AD caused by house dust mites. Here, we present a meta-analysis comparing APT to the common skin prick test (SPT) in the diagnosis of mite-induced AD. A structured search was performed using online databases and bibliographies published as of April 30, 2017. All studies evaluating the accuracy of APT and SPT in the diagnosis of mite-induced atopic eczema/dermatitis syndrome were selected, appraised, and data was extracted. Ten studies were identified for inclusion in our analysis. Meta-analysis revealed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratios for APT were 0.54 (95% CI 0.42–0.66), 0.72 (95% CI 0.56–0.85), 1.97 (95% CI 1.20–3.23), 0.63 (95% CI 0.48–0.83), and 3.12 (95% CI 1.53–6.39). The area under the summary receiver operating characteristic curve was 0.65 (95% CI 0.61–0.69). Our analysis indicates that APT is a useful tool in the screening of mite-induced AD, although this conclusion must be interpreted cautiously due to high heterogeneity among the included studies.
机译：接触屋尘螨，花粉和动物皮屑等空气过敏原后，可发生特应性皮炎（AD）。尽管其争议性的诊断价值，特应性斑贴试验（APT）已被用作诊断由屋尘螨引起的AD的重要工具。在这里，我们提出了一项荟萃分析，将APT与普通皮肤点刺试验（SPT）在螨虫诱发的AD的诊断中进行比较。使用截至2017年4月30日发布的在线数据库和书目进行结构化搜索。选择，评估和评估所有评估APT和SPT在螨诱发的特应性湿疹/皮炎综合征诊断中的准确性的研究。确定了十项研究以纳入我们的分析。荟萃分析显示，APT的综合敏感性，特异性，阳性似然比，阴性似然比和诊断比值比分别为0.54（95％CI 0.42-0.66），0.72（95％CI 0.56-0.85），1.97（95％） CI 1.20-3.23），0.63（95％CI 0.48-0.83）和3.12（95％CI 1.53-6.39）。摘要接收器工作特性曲线下的面积为0.65（95％CI 0.61-0.69）。我们的分析表明，APT是筛选螨虫诱发的AD的有用工具，尽管由于所纳入研究之间的高度异质性，必须谨慎解释这一结论。

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