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首页> 外文期刊>Clinical and Translational Allergy >Incidence of anxiety and depression in a predominantly HIV-infected population with severe adverse drug reactions
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Incidence of anxiety and depression in a predominantly HIV-infected population with severe adverse drug reactions

机译：主要感染药物的严重艾滋病毒感染人群中焦虑和抑郁的发生率

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BackgroundLittle is known on the short-term or medium-term psychologicaland psychiatric sequelae following StevensJohnson syndrome (SJS), toxic epidermal necrolysis (TEN)and drug reaction with eosinophilia and systemic symptoms(DRESS). Based on this we did a prospective studydesigned to assess anxiety and depression in patients withsevere cutaneous adverse drug reactions by indicatinghigher Hospital anxiety and depression scale (HADS).MethodsWe prospectively assessed 46 consecutive admissions withSJS, TEN and DRESS at a tertiary hospital in South Africaat 6 weeks and 6 months post discharge from hospital. Weused a validated scoring system Hospital anxiety anddepression scale (HADS) to assess anxiety and depressivein this cohort.ResultsForty-six patients were seen at six weeks and (n=38) 83%were reviewed at 6 months. Seventy-six percent of the participantswere females and 82% were HIV-infected. Anxietyand depression were diagnosed in 37% and 30% respectivelywith six weeks with 8.6% exhibiting mixed anxietyand depressive symptoms. In comparison, at six months13% had anxiety, 55% were depressed and 18.4% showedmixed anxiety and depressive symptoms. Nine and eightpercent respectively at six weeks and six months warrantedreferral to a psychiatrist. Twenty-five percent of patientshad anxiety and 40% had depression throughout the wholesix months. The incidence of anxiety and depression wassignificantly associated with severity of the drug reaction.InterpretationSJS/TEN and DRESS are associated with anxiety anddepression for at least 6 months. SJS/TEN showed higherdegree of anxiety and depression compares to DRESS. Ourfindings should help to improve awareness of psychologicalimpact of severe adverse skin reactions as these mayimpact on treatment compliance.
机译：背景对于史蒂文斯·约翰逊综合征（SJS），中毒性表皮坏死溶解（TEN）以及伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）的短期或中期心理和精神病后遗症知之甚少。在此基础上，我们进行了一项前瞻性研究，旨在通过指示较高的医院焦虑和抑郁量表（HADS）来评估具有严重皮肤不良药物反应的患者的焦虑和抑郁症。方法我们在南非一家三级医院中对46例SJS，TEN和DRESS连续入院进行了前瞻性评估6出院后几个星期零六个月。我们使用经过验证的评分系统医院焦虑和抑郁量表（HADS）评估该队列中的焦虑和抑郁情绪。结果在46周时观察了46例患者，在6个月时进行了复查（n = 38）83％。百分之七十六的参与者是女性，百分之八十二是艾滋病毒感染者。六周诊断出焦虑和抑郁的比例分别为37％和30％，其中8.6％表现出混合焦虑和抑郁症状。相比之下，六个月时有13％的人有焦虑，55％的人有抑郁，18.4％的人有焦虑和抑郁的综合症状。在六个星期和六个月时，分别有9％和8％的人转诊给精神病医生。在整个六个月中，有25％的患者患有焦虑症，有40％的患者患有抑郁症。焦虑和抑郁的发生与药物反应的严重程度显着相关。解释SJS / TEN和DRESS与焦虑和抑郁有关至少6个月。与DRESS相比，SJS / TEN显示出更高的焦虑和抑郁程度。我们的发现应有助于提高人们对严重不良皮肤反应的心理影响的认识，因为这些反应可能会影响治疗依从性。

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