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首页> 外文期刊>Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine >Use of Noninvasive Gas Exchange to Track Pulmonary Vascular Responses to Exercise in Heart Failure
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Use of Noninvasive Gas Exchange to Track Pulmonary Vascular Responses to Exercise in Heart Failure

机译：使用无创气体交换追踪心力衰竭对运动的肺血管反应

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We determined whether a non-invasive gas exchange based estimate of pulmonary vascular (PV) capacitance [PVCAP = stroke volume (SV) × pulmonary arterial pressure (Ppa)] (GXCAP) tracked the PV response to exercise in heart-failure (HF) patients. Pulmonary wedge pressure (Ppw), Ppa, PV resistance (PVR), and gas exchange were measured simultaneously during cycle exercise in 42 HF patients undergoing right-heart catheterization. During exercise, PETCO2 and VE/VCO2 were related to each other (r = ?0.93, P < 0.01) and similarly related to mean Ppa (mPpa) (r = ?0.39 and 0.36; P < 0.05); PETCO2 was subsequently used as a metric of mPpa. Oxygen pulse (O2 pulse) tracked the SV response to exercise (r = 0.91, P < 0.01). Thus, GXCAP was calculated as O2 pulse × PETCO2. During exercise, invasively determined PVCAP and non-invasive GXCAP were related (r = 0.86, P < 0.01), and GXCAP correlated with mPpa and PVR (r = ?0.46 and ?0.54; P < 0.01). In conclusion, noninvasive gas exchange measures may represent a simple way to track the PV response to exercise in HF.
机译：我们确定了基于无创气体交换的肺血管（PV）电容估计值[PVCAP =中风量（SV）×肺动脉压（Ppa）]（GXCAP）是否跟踪了心衰（HF）对运动的PV反应耐心。在42例接受右心导管检查的HF患者的循环运动期间，同时测量了肺楔压（Ppw），Ppa，PV阻力（PVR）和气体交换。在运动过程中，PETCO2和VE / VCO2彼此相关（r = 0.93，P <0.01），并且与平均Ppa（mPpa）相关（r = 0.39和0.36; P <0.05）。随后将PETCO2用作mPpa的度量。氧气脉冲（O2脉冲）追踪了SV对运动的反应（r = 0.91，P <0.01）。因此，将GXCAP计算为O2脉冲×PETCO2。在运动过程中，有创测定的PVCAP和无创GXCAP相关（r = 0.86，P <0.01），GXCAP与mPpa和PVR相关（r = 0.46和0.54; P <0.01）。总而言之，无创气体交换措施可能代表一种追踪PV在HF中运动的简单方法。

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