Pharmacokinetics and Pharmacodynamics of Piperacillin-Tazobactam in 42 Patients Treated with Concomitant CRRT

Ashita J. Tolwani; Charbel Salem; Joseph Groszek; Maria E. Taylor; Michael J. Connor Jr.; Peilin Wei; Seth R. Bauer; William H. Fissell

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Pharmacokinetics and Pharmacodynamics of Piperacillin-Tazobactam in 42 Patients Treated with Concomitant CRRT

机译：哌拉西林-他唑巴坦在CRRT合并治疗的42例患者中的药代动力学和药效学

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Background and objectives Current recommendations for piperacillin-tazobactam dosing in patients receiving continuous renal replacement therapy originate from studies with relatively few patients and lower continuous renal replacement therapy doses than commonly used today. This study measured the pharmacokinetic and pharmacodynamic characteristics of piperacillin-tazobactam in patients treated with continuous renal replacement therapy using contemporary equipment and prescriptions.

机译：背景和目的当前对接受连续性肾脏替代治疗的患者进行哌拉西林-他唑巴坦给药的建议源于相对较少的患者研究，并且连续性肾脏替代治疗剂量低于当今常用剂量。这项研究测量了哌拉西林-他唑巴坦在使用连续性肾脏替代疗法治疗的患者中使用现代设备和处方的药代动力学和药效学特征。

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《Clinical journal of the American Society of Nephrology: CJASN》 |2012年第3期|共页
作者
Ashita J. Tolwani; Charbel Salem; Joseph Groszek; Maria E. Taylor; Michael J. Connor Jr.; Peilin Wei; Seth R. Bauer; William H. Fissell;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Pharmacokinetics and Pharmacodynamics of Piperacillin-Tazobactam in 42 patients treated with Concomitant CRRT [J] . BauerS.R., SalemC., ConnorJr.M.J., Clinical journal of the American Society of Nephrology: CJASN . 2012,第3期

机译：哌拉西林-他唑巴坦在伴CRRT治疗的42例患者中的药代动力学和药效学
2. Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT [J] . Shotwell Matthew S., Nesbitt Ross, Madonia Phillip N., Clinical journal of the American Society of Nephrology: CJASN . 2016,第8期

机译：严重输注CRRT的重症患者中，延长输注与短暂输注哌拉西林-他唑巴坦的药代动力学和药效学
3. Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients [J] . Heil Emily L., Nicolau David P., Farkas Andras, Antimicrobial agents and chemotherapy. . 2018,第9期

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4. Pre- and Short-term Posttreatment Vocal Functioning in Patients with Advanced Head and Neck Cancer Treated with Concomitant Chemoradiotherapy [C] . Irene Jacobi, Lisette van der Molen, Maya van Rossum, Annual conference of the International Speech Communication Association;INTERSPEECH 2010 . 2011

机译：伴放化疗治疗晚期头颈癌患者的治疗前后声带功能
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6. Pharmacodynamic Target Attainment for Cefepime Meropenem and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients [O] . Emily L. Heil, David P. Nicolau, Andras Farkas, 2018

机译：头孢吡肟美洛培南和哌拉西林-他唑巴坦使用药代动力学/基于药效学的剂量计算器在重症患者中的药效学目标达成
7. Pharmacokinetics of piperacillin-tazobactam in plasma, peritoneal fluid and peritoneum of surgery patients, and dosing considerations based on site-specific pharmacodynamic target attainment [O] . Naoki Murao, Hiroki Ohge, Kazuro Ikawa, 2017

机译：哌啶蓟素 - 唑唑米在血浆，腹膜液和腹膜腹膜腹膜腹膜腹膜内的药代动力学，以及基于现场特异性药学目标达到的给药考虑因素

Pharmacokinetics and Pharmacodynamics of Piperacillin-Tazobactam in 42 Patients Treated with Concomitant CRRT

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