Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT

Shotwell Matthew S.; Nesbitt Ross; Madonia Phillip N.; Gould Edward R.; Connor Michael J.; Salem Charbel; Aduroja Olufemi A.; Amde Milen; Groszek Joseph J.; Wei Peilin; Taylor Maria E.; Tolwani Ashita J.; Fissell William H.

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Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT

机译：严重输注CRRT的重症患者中，延长输注与短暂输注哌拉西林-他唑巴坦的药代动力学和药效学

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Background and objectives Infection is the most common cause of death in severe AKI, but many patients receiving continuous RRT do not reach target antibiotic concentrations in plasma. Extended infusion of beta-lactams is associated with improved target attainment in critically ill patients; thus, we hypothesized that extended infusion piperacillin-tazobactam would improve piperacillin target attainment compared with short infusion in patients receiving continuous RRT.

机译：背景和目标感染是严重AKI中最常见的死亡原因，但是许多接受连续RRT的患者血浆中的抗生素浓度均未达到目标。长期输注β-内酰胺类药物可改善危重患者的靶标达成率;因此，我们假设与接受连续RRT的短期输注相比，延长输注哌拉西林-他唑巴坦会提高哌拉西林的靶标达成率。

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《Clinical journal of the American Society of Nephrology: CJASN》 |2016年第8期|共7页
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Shotwell Matthew S.; Nesbitt Ross; Madonia Phillip N.; Gould Edward R.; Connor Michael J.; Salem Charbel; Aduroja Olufemi A.; Amde Milen; Groszek Joseph J.; Wei Peilin; Taylor Maria E.; Tolwani Ashita J.; Fissell William H.;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
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1. Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT [J] . Shotwell Matthew S., Nesbitt Ross, Madonia Phillip N., Clinical journal of the American Society of Nephrology: CJASN . 2016,第8期

机译：严重输注CRRT的重症患者中，延长输注与短暂输注哌拉西林-他唑巴坦的药代动力学和药效学
2. Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used? [J] . Mieke Carlier, Sofie Carrette, Jason A Roberts, Critical care : . 2013,第3期

机译：美罗培南和哌拉西林/他唑巴坦在危重患者中开处方：使用长时间输注时，增加的肾脏清除率是否会影响药代动力学/药效学目标的实现？
3. Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used? [J] . Mieke Carlier, Sofie Carrette, Jason A Roberts, Critical care : . 2013,第3期

机译：美罗培南和哌拉西林/他唑巴坦在危重患者中开处方：使用长时间输注时，增加的肾脏清除率是否会影响药代动力学/药效学目标的实现？
4. Adaptive multi-infusion decision support for the multivariable circulatory management of critically ill patients [C] . Mason David G., Bancroft Jayne, Fraser John F. 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2010

机译：适应性多输注决策支持，用于危重患者的多变量循环管理
5. Pharmacokinetics of cimetidine in plasma and skin following IV-infusion administration in a rabbit model. [D] . Pandya, Ruchita. 2009

机译：西咪替丁在兔子模型中静脉输注后在血浆和皮肤中的药代动力学。
6. Population Pharmacokinetics and Pharmacodynamics of Continuous versus Short-Term Infusion of Imipenem-Cilastatin in Critically Ill Patients in a Randomized Controlled Trial [O] . Samir G. Sakka, Anna K. Glauner, Jürgen B. Bulitta, 2007

机译：随机对照试验中连续或短期输注亚胺培南-西拉他汀在危重患者中的群体药代动力学和药效学
7. Population Pharmacokinetics and Pharmacodynamics of Continuous versus Short-Term Infusion of Imipenem-Cilastatin in Critically Ill Patients in a Randomized, Controlled Trial▿ [O] . Sakka, Samir G., Glauner, Anna K., Bulitta, Jürgen B., 2007

机译：在一项随机对照试验中，连续或短期输注亚胺培南-西拉他汀在危重患者中的群体药代动力学和药效动力学▿
8. Serum Vancomycin Levels Resulting from Continuous or Intermittent Infusion in Critically Ill Burn Patients With or Without Continuous Renal Replacement Therapy. [R] . Akers, K. S., Cota, J. M., Chung, K. K., 2012

机译：连续或间歇性输注的血清万古霉素水平在有或没有连续肾脏替代疗法的重症烧伤患者中。

Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT

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