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首页> 外文期刊>Clinical kidney journal. >Clinical management of patients on peritoneal dialysis in Italy: results from the ATENA study
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Clinical management of patients on peritoneal dialysis in Italy: results from the ATENA study

机译：意大利腹膜透析患者的临床管理：ATENA研究的结果

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Background In Italy, few studies have examined the clinical management of peritoneal dialysis (PD) patients, resulting in a lack of information and awareness. Methods A total of 378 PD patients (64.7?±?14.3?years, 58.9% males) were enrolled across 15 centres in a 12-month retrospective and 6-month prospective study. The primary objective was to evaluate the achievement of Kidney Disease Outcomes Quality Initiative and Kidney Disease Improving Global Outcomes guidelines on recommended target values for anaemia, high blood pressure and mineral metabolism. Comorbidities, hospitalizations, treatment and quality of life were also assessed. Results Frequent comorbidities included hypertension (87.8%) and cardiovascular disease (39.7%). Peritonitis was the leading cause of hospitalization [12 admissions per 100 person-years (95% confidence interval 9.3–15.2)]. At 6?months, anaemia corrected by erythropoiesis-stimulating agents was observed in 30% of patients and 73% received erythropoiesis-stimulating agents. Systolic and diastolic blood pressures were recorded in 50% and 20% of patients, respectively. Sixty-four percent of echocardiograms revealed left ventricular hypertrophy and 30% of patients had vitamin D?<10?ng/mL. Medication to treat intact parathyroid hormone (PTH) included calcitriol (36.3%), paricalcitol (29.2%), cholecalciferol (23.6%) and cinacalcet (21.5%). In a subgroup of patients matched for baseline PTH treated for 1?year, a significant reduction in PTH with paricalcitol (?41%; P?
机译：背景技术在意大利，很少有研究检查腹膜透析（PD）患者的临床管理，导致缺乏信息和意识。方法回顾性分析了12个回顾性研究和6个月前瞻性研究，共在15个中心纳入了378名PD患者（64.7±14.3岁，男性58.9％）。主要目标是评估针对贫血，高血压和矿物质代谢的推荐目标值的《肾脏疾病成果质量计划》和《肾脏疾病改善全球成果指南》的实现情况。还评估了合并症，住院，治疗和生活质量。结果常见合并症包括高血压（87.8％）和心血管疾病（39.7％）。腹膜炎是住院的主要原因[每100人年12次入院（95％置信区间9.3-15.2）]。在6个月时，在30％的患者中观察到由促红细胞生成剂纠正的贫血，而73％的患者接受了促红细胞生成剂。分别记录了50％和20％的患者的收缩压和舒张压。 64％的超声心动图显示左心室肥大，30％的患者维生素D <10？ng / mL。治疗完整甲状旁腺激素（PTH）的药物包括骨化三醇（36.3％），帕立骨化醇（29.2％），胆钙化醇（23.6％）和西那卡塞（21.5％）。在与基线PTH相符的为期1年的患者亚组中，观察到使用paricalcitol的PTH显着降低（≥41％; P 0.001），但未观察到西那卡塞（+ 2％;P≥0.63）。生活质量域的比较显示出症状（P = 0.049），认知功能（P = 0.019）和社会支持（P = 0.04）有显着差异（基线与6个月）。结论高血压和心血管疾病是常见的合并症，腹膜炎是住院的主要原因。继发性甲状旁腺功能亢进和贫血很常见，因此需要经常监测PTH，钙，磷和血红蛋白。

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