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首页> 外文期刊>Clinical kidney journal. >Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative features
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Steroid-responsive nephrotic syndrome in a patient with proliferative glomerulonephritis with monoclonal IgG deposits with pure mesangial proliferative features

机译：具有单纯肾小球膜增生特征的单克隆IgG沉积的增生性肾小球肾炎患者的类固醇反应性肾病综合征

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摘要

A 78-year-old woman developed acute-onset nephrotic syndrome. A renal biopsy showed mild mesangial proliferative glomerulonephritis. Immunofluorescence studies revealed granular IgG3- λ deposits within the mesangial area and along the glomerular capillary walls. Electron microscopy showed mesangial and subendothelial granular electron-dense deposits. The pattern of deposition was predominantly mesangial. Serum or urine monoclonal proteins were not detected. Middle-dose steroid therapy induced a rapid remission of nephrotic syndrome. We consider that this is the first case of steroid-responsive nephrotic syndrome due to an extremely rare glomerular disease, proliferative glomerulonephritis with monoclonal IgG deposits associated with pure mesangial proliferative features.
机译：一名78岁的妇女患上了急性发作性肾病综合征。肾活检显示轻度系膜增生性肾小球肾炎。免疫荧光研究显示，肾小球系膜区域和肾小球毛细血管壁上有颗粒状IgG3-λ沉积。电子显微镜显示肾小球系膜和内皮下颗粒状的电子致密沉积物。沉积模式主要是肾小球系膜。未检测到血清或尿液单克隆蛋白。中剂量类固醇疗法可迅速缓解肾病综合征。我们认为这是类固醇反应性肾病综合征的首例病例，这是由于一种极为罕见的肾小球疾病，即具有单克隆IgG沉积物并伴有纯系膜增生特征的增生性肾小球肾炎。

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