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首页> 外文期刊>Clinical ophthalmology >Detection of retinal changes in Parkinson's disease with spectral-domain optical coherence tomography
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Detection of retinal changes in Parkinson's disease with spectral-domain optical coherence tomography

机译：光谱域光学相干断层扫描技术检测帕金森氏病的视网膜变化

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Purpose: This pilot study investigated whether high-resolution spectral-domain optical coherence tomography (SD-OCT) could detect differences in inner retinal layer (IRL), peripapillary retinal nerve fiber layer (RNFL), and macular thickness between patients with Parkinson's disease (PD) and controls.Methods: Both eyes of patients with PD and age-matched controls were imaged with the Heidelberg Spectralis? HRA + OCT. RNFL, IRL, and macular thickness were measured for each eye using Heidelberg software. These measurements were compared with validated, published normal values for macular and RNFL thickness, and compared with matched controls for IRL thickness.Results: Eighteen eyes from nine subjects with PD and 19 eyes of 16 control subjects were evaluated using SD-OCT. The average age of PD patients was 64 years with a range of 52–75 years. The average age of controls was 67 years with a range of 50–81 years. No significant reduction in IRL thickness was detected between PD patients and age-matched controls at 13 points along a 6 mm horizontal section through the fovea. No significant difference in RNFL thickness was detected between PD patients and published normal values. Overall average RNFL thickness was 97 μm for PD patients, which exactly matched the normative database value. However, significant differences in macular thickness were detected in three of nine subfields between PD subjects and published normal values. In PD subjects, the outer superior subfield was 2.8% thinner (P = 0.026), while the outer nasal and inner inferior subfields were 2.8% (P = 0.016) and 2.7% (P = 0.001) thicker compared to published normal values.Conclusion: In this pilot study, significant differences in macular thickness were detected in three of nine subfields by SD-OCT. However, SD-OCT did not detect significant reductions in peripapillary RNFL and IRL thickness between PD patients and controls. This suggests that macular thickness measurements by SD-OCT may potentially be used as an objective, noninvasive, and easily quantifiable in vivo biomarker in PD. Larger, longitudinal studies are needed to explore these relationships further.
机译：目的：这项初步研究调查了高分辨率光谱域光学相干断层扫描（SD-OCT）是否可以检测帕金森氏病患者之间的视网膜内层（IRL），乳头周围视网膜神经纤维层（RNFL）和黄斑厚度的差异（方法：PD患者和年龄匹配的对照者的两只眼睛都用Heidelberg Spectralis成像。 HRA + OCT。使用Heidelberg软件测量每只眼睛的RNFL，IRL和黄斑厚度。将这些测量值与经过验证的公布的黄斑和RNFL厚度正常值进行比较，并与匹配的IRL厚度对照进行比较。结果：使用SD-OCT对来自9名PD受试者的18只眼和16名对照受试者的19只眼进行了评估。 PD患者的平均年龄为64岁，范围为52-75岁。对照的平均年龄为67岁，范围为50-81岁。在PD患者和年龄匹配的对照组中，在沿着中央凹的6毫米水平截面的13个点处，未检测到IRL厚度显着降低。在PD患者和公布的正常值之间未检测到RNFL厚度的显着差异。 PD患者的平均RNFL总厚度为97μm，与标准数据库值完全匹配。但是，在PD受试者和公布的正常值之间的九个子场中的三个中，检测到了黄斑厚度的明显差异。在PD受试者中，与已发表的正常值相比，外上子视野薄2.8％（P = 0.026），而外鼻和内下视野分别厚2.8％（P = 0.016）和2.7％（P = 0.001）。 ：在这项初步研究中，通过SD-OCT在9个子场中的3个子场中检测到了黄斑厚度的显着差异。但是，SD-OCT并未检测到PD患者与对照组之间的乳头周围RNFL和IRL厚度显着降低。这表明通过SD-OCT进行的黄斑厚度测量可潜在地用作PD中的客观，无创且易于量化的体内生物标志物。需要更大的纵向研究来进一步探索这些关系。

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