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首页> 外文期刊>Investigative ophthalmology & visual science >Outer Retinal Assessment Using Spectral-Domain Optical Coherence Tomography in Patients With Alzheimer's and Parkinson's Disease
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Outer Retinal Assessment Using Spectral-Domain Optical Coherence Tomography in Patients With Alzheimer's and Parkinson's Disease

机译：阿尔茨海默氏病和帕金森氏病患者使用光谱域光学相干断层扫描技术进行外部视网膜评估

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Purpose : To investigate outer retinal parameters among patients with various chronic neurodegenerative disorders by using spectral-domain coherence tomography (OCT) in a prospective cross-sectional cohort study. Methods : A total of 132 participants were enrolled following a comprehensive diagnostic evaluation with neurologic, neuropsychology, and magnetic resonance imaging volumetric evaluations. Participants were 50 years or older, either diagnosed with Alzheimer's disease (AD) dementia, amnestic mild cognitive impairment (MCI), non-AD dementia, Parkinson's disease (PD), or age- and sex-matched controls. All participants underwent a macular cube scan for both eyes by using the Cirrus 4000 HD-OCT (Zeiss, Oberkochen, Germany). The OCT image with the best quality was selected for further analysis. Outer retinal parameters including ellipsoid zone mapping and outer nuclear layer metrics were evaluated with a novel software platform. Results : One hundred twenty-four eyes of 124 participants with AD dementia (24 eyes), amnestic MCI (22 eyes), non-AD dementia (20 eyes), PD (22 eyes), and age- and sex-matched controls (36 eyes) were included in the analysis. Eight eyes were excluded either due to the presence of macular disease or poor quality of the OCT image. The mean ages of participants were 65.9 ± 8.9 years. The outer retinal thickness measures did not show any statistical significance between the groups. However, ellipsoid zone to retinal pigment epithelium volume correlated with cognitive testing scores in all study participants. Conclusions : There were no identifiable differences in the outer retinal metrics across neurodegenerative disease groups and controls. The relationship between the degree of cognitive impairment and ellipsoid zone to retinal pigment epithelium volume warrants further study.
机译：目的：在前瞻性横断队列研究中，通过使用光谱域相干断层扫描（OCT）研究各种慢性神经退行性疾病患者的外部视网膜参数。方法：经过神经，神经心理学和磁共振成像体积评估的综合诊断评估，总共招募了132名参与者。参与者年龄在50岁或50岁以上，被诊断患有阿尔茨海默氏病（AD）痴呆，轻度遗忘性轻度认知障碍（MCI），非AD痴呆，帕金森氏病（PD）或年龄和性别匹配的对照。所有参与者均使用Cirrus 4000 HD-OCT（德国Oberkochen的蔡司）进行了双眼的黄斑立方体扫描。选择质量最好的OCT图像进行进一步分析。使用新型软件平台评估了外部视网膜参数，包括椭球区映射和核外层度量。结果：124名患有AD痴呆的参与者（124眼），失忆性MCI（22眼），非AD痴呆（20眼），PD（22眼）以及年龄和性别匹配的对照（124眼）的124眼分析中包括36只眼睛。由于存在黄斑疾病或OCT图像质量较差而排除了八只眼睛。参与者的平均年龄为65.9±8.9岁。两组之间的视网膜外层厚度测量值没有显示任何统计学意义。然而，在所有研究参与者中，椭球区到视网膜色素上皮的体积与认知测试得分相关。结论：在神经退行性疾病组和对照组中，外部视网膜指标没有可识别的差异。认知障碍程度和椭球区与视网膜色素上皮体积之间的关系值得进一步研究。

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