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IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations

机译:美学中的肉毒杆菌毒素A:俄罗斯多学科专家共识建议

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Background: Although there are various international consensus recommendations on the use of botulinum neurotoxin type A (BoNT/A) in facial aesthetics, there are no global or Russian guidelines on the optimal dose of incobotulinumtoxinA, free from complexing proteins, within specific aesthetic indications. This article reports the outcomes of two expert consensus meetings, conducted to review and analyze efficacy and tolerability data for incobotulinumtoxinA in various facial aesthetic indications and to give expert consensus recommendations to ensure best clinical practice among Russian clinicians. Methods: Thirteen dermatology and/or plastic surgery experts attended meetings held in Paris, France (November 2013), and Moscow, Russia (March 2014). The expert group reviewed and analyzed the existing evidence, consensus recommendations, and Russian experts’ extensive practical experience of incobotulinumtoxinA in aesthetics to reach consensus on optimal doses, potential dose adjustments, and injection sites of incobotulinumtoxinA for facial aesthetics. Results: All experts developed guidance on the optimal doses for incobotulinumtoxinA treatment of different regions of the upper and lower face. The expert panel agreed that there are no differences in the efficacy and duration of the effect between the four BoNT/As that are commercially available for facial aesthetic indications in Russia and that, when administered correctly, all BoNT/As can achieve optimal results. Experts also agreed that nonresponse to BoNT/A can be caused by neutralizing antibodies. Conclusion: On the basis of the scientific and clinical evidence available for incobotulinumtoxinA, coupled with the extensive clinical experience of the consensus group, experts recommended the optimal doses of incobotulinumtoxinA effective for treatment of wrinkles of the upper and lower face to achieve the expected aesthetic outcome. These first Russian guidelines on the optimal use of incobotulinumtoxinA for augmentation of glabellar lines, periorbital wrinkles, forehead lines, bunny lines, perioral wrinkles, depressor anguli oris, mentalis, masseters and platysmal bands, and performing the Nefertiti lift, are presented here.
机译:背景:尽管在面部美容中有关于使用A型肉毒杆菌神经毒素(BoNT / A)的国际共识,但在特定的美学适应症范围内,尚无全球或俄罗斯的关于不包含复杂蛋白的最佳Incobotulinum毒素A剂量的全球指南。本文报告了两次专家共识会议的成果,该会议旨在审查和分析incobotulinumtoxinA在各种面部美容适应症中的功效和耐受性数据,并提出专家共识建议,以确保俄罗斯临床医生中的最佳临床实践。方法:13名皮肤病学和/或整形外科专家参加了在法国巴黎(2013年11月)和俄罗斯莫斯科(2014年3月)举行的会议。专家组审查并分析了现有的证据,共识性建议以及俄罗斯专家在美容方面对incobotulinumxinA的广泛实践经验,以就面部美容方面的最佳剂量,潜在剂量调整以及incobotulinumxinA的注射部位达成共识。结果:所有专家均制定了针对上,下面部不同区域的肌肉毒杆菌毒素A治疗最佳剂量的指南。专家小组一致认为,俄罗斯可用于面部美容适应症的四种BoNT / A在疗效和持续时间上没有差异,而且,如果正确使用,所有BoNT / A均可达到最佳效果。专家们还同意,对BoNT / A的无反应可能是由中和抗体引起的。结论:根据现有的科学和临床证据,incobotulinumtoxinA结合共识组的广泛临床经验,专家建议使用有效剂量的incobotulinumtoxinA治疗上,下面部皱纹,以达到预期的美学效果。此处介绍了有关最佳使用IncobotulinumtoxinA来增强间质皱纹,眶周皱纹,前额纹,兔子纹,口周皱纹,降压性Angulis,mentis,咬肌和胸膜带以及进行Nefertiti提拉的俄罗斯第一本指南。

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