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Drug-induced skin reactions: a 2-year study

机译：药物引起的皮肤反应：为期2年的研究

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Background: The aim of this study was to analyze the clinical characteristics of patients with adverse cutaneous drug reactions, which occur when a medicinal product results in cutaneous morbidity. Methods: The study included 308 patients who were diagnosed as having an adverse cutaneous drug reaction during the study period (2007–2009). In 84 cases, histopathologic examination of skin biopsies were also performed. Results: Patients with drug reactions were found to be more commonly female (63%) than male (37%). Beta-lactam antibiotics were found to be the most frequent cause of adverse cutaneous drug reactions (42.7%), followed by non-steroidal anti-inflammatory drugs (16.5%). Acute urticaria was the most common clinical presentation (59.2%) followed by fixed drug eruptions (18.5%), and maculopapular eruptions (14.9%). Conclusion: Adverse cutaneous drug reactions in our study population were mainly induced by beta-lactam antibiotics and non-steroidal anti-inflammatory drugs. The most common forms of cutaneous adverse drug reactions were found to be acute urticaria, fixed drug eruptions, and maculopapular rashes.
机译：背景：本研究的目的是分析皮肤药物不良反应患者的临床特征，这些药物在药物导致皮肤疾病时会发生。方法：该研究纳入了308名在研究期间（2007- 2009年）被诊断为皮肤药物不良反应的患者。在84例中，还进行了皮肤活检的组织病理学检查。结果：发现有药物反应的患者女性（63％）比男性（37％）更常见。发现β-内酰胺类抗生素是引起皮肤药物不良反应的最常见原因（42.7％），其次是非甾体类抗炎药（16.5％）。急性荨麻疹是最常见的临床表现（59.2％），其次是固定药疹（18.5％）和斑丘疹（14.9％）。结论：我们研究人群的皮肤药物不良反应主要由β-内酰胺类抗生素和非甾体类抗炎药引起。皮肤不良药物反应的最常见形式是急性荨麻疹，固定性药疹和斑丘疹。

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