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首页> 外文期刊>Clinical, Cosmetic and Investigational Dermatology >A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial
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A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial

机译：含有爆米花，银杏叶提取物和甘露醇的皮肤美容剂可提高阿达帕林对寻常型痤疮患者的疗效：一项随机对照试验的结果

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Background: Acne vulgaris is an inflammatory disorder of the pilosebaceous unit. Aim: To confirm that BGM (bakuchiol, Ginkgo biloba extract, and mannitol) complex increases the established clinical efficacy of adapalene 0.1% gel in patients with acne. Methods: A clinical trial was conducted in acne patients. A total of 111 subjects received adapalene 0.1% gel and BGM complex or vehicle cream for 2 months. Assessments comprised Investigator Global Assessment (IGA), global efficacy, seborrhea intensity, inflammatory and non-inflammatory lesions, and subject perception, as well as overall safety and local tolerance and quality of life. Results: At the end of the trial, inflammatory and non-inflammatory lesions, IGA, global efficacy, and seborrhea intensity had significantly improved in both treatment groups. Differences were statistically significant (P<0.05) in favor of BGM complex for inflammatory lesions as well as IGA and seborrhea intensity. Global efficacy assessments and subject perception confirmed the superiority of BGM complex-including treatment over the comparative combination. Quality of life had improved more with the active combination than with the vehicle combination. In the active group, four subjects had to interrupt temporarily BGM complex and 12 adapalene compared to seven subjects interrupting the vehicle and eleven adapalene in the vehicle group. One subject withdrew from the trial due to an allergy to adapalene. The majority of all events were mild. Conclusion: BGM complex improves the treatment outcome of adapalene 0.1% gel in patients with acne vulgaris. Overall, safety and local tolerance of BGM complex were good.
机译：背景：寻常痤疮是毛囊皮脂腺炎性疾病。目的：为了证实BGM（爆米花，银杏叶提取物和甘露醇）复合物可提高痤疮患者0.1％的阿达帕林凝胶临床疗效。方法：对痤疮患者进行了一项临床试验。共有111名受试者接受了2个月阿达帕林0.1％凝胶和BGM复合物或赋形剂乳膏治疗。评估包括研究者全球评估（IGA），整体疗效，皮脂溢出强度，炎性和非炎性病变，受试者知觉，以及总体安全性，局部耐受性和生活质量。结果：在试验结束时，两个治疗组的炎症性和非炎症性病变，IGA，整体疗效和皮脂溢强度均得到明显改善。 BGM复合物在炎性病变，IGA和皮脂溢出强度方面的差异具有统计学意义（P <0.05）。全球疗效评估和受试者认知证实了BGM复合物（包括治疗）优于比较组合的优越性。主动组合的生活质量比车辆组合的生活质量得到了更大的改善。在活动组中，有四名受试者必须暂时中断BGM复合物和12颗阿达帕林，而在车辆组中有七名受试者中断了车辆和十一名阿达帕林。一个受试者由于对阿达帕林过敏而退出了试验。所有事件大多数都是轻微的。结论：BGM复合物可改善寻常痤疮患者0.1％阿达帕林凝胶的治疗效果。总体而言，BGM复合物的安全性和局部耐受性良好。

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