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首页> 外文期刊>Clinical, Cosmetic and Investigational Dermatology >Clinical evaluation of a water-in-oil emulsion with protective and regenerative properties for the anogenital area
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Clinical evaluation of a water-in-oil emulsion with protective and regenerative properties for the anogenital area

机译：具有生殖和生殖功能的油包水型乳剂的临床评价

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Inadequate hygiene, aggressive cleansing, and chafing skin folds, as well as urine, feces, and sweat may trigger irritative contact dermatitis in the anogenital area. Serious recommendations for protection of the skin toward irritants include hygienic aspects and the use of appropriate skin care. Furthermore, preventing an accumulation of irritants on unprotected skin is mandatory. An intraindividual comparison study with 30 participants (17 female, 13 male; age: 44.2±8.3 years) was performed to evaluate the properties of a newly developed water-in-oil (W/O) balm on artificial sodium dodecyl sulfate-damaged epidermal barrier. The balm was applied 14 days twice daily, and transepidermal water loss and erythema were investigated. A significant improvement of both parameters after 12 days and even after 21 days could be confirmed. Two major clinical trials were performed to evaluate the safety and efficacy regarding protective and regenerative properties of the W/O balm on irritated skin in the anogenital area. Therefore, 29 children were enrolled (14 male, 15 female, age: 15.5±7.8 months) in an open-labeled 4-week clinical study. The balm was used in the area under disposable diapers at least after diaper change or if required. Furthermore, in a second open, multicenter study, 43 women (mean age: 46.2±16.9) with predisposition to skin irritation in the outer anogenital region were included. The product was applied for 4 weeks 1–2 times daily. In both studies, skin tolerability, applicability, scent, spreadability, and removability of the balm were evaluated by participants and practitioners predominantly as good or even very good, also skin hydration, protection, and regeneration were judged positively. The studies confirmed that the newly developed W/O balm exhibits excellent tolerability and is easy to remove. At the same time, excellent properties with respect to efficacy regarding regeneration and protection could be observed, without any undesired effects at any time.
机译：卫生不足，清洁过度和皮肤皱褶以及尿液，粪便和汗水擦伤，可能会在肛门生殖器部位引发刺激性接触性皮炎。保护皮肤免受刺激的严重建议包括卫生方面和使用适当的皮​​肤护理。此外，必须防止刺激物积聚在未保护的皮肤上。进行了一项针对30名参与者（17名女性，13名男性;年龄：44.2±8.3岁）的个人比较研究，以评估新开发的油包水（W / O）香脂在十二烷基硫酸钠硫酸钠损伤的表皮上的性能。屏障。每天两次，每天两次，每天14天使用润唇膏，并研究了表皮失水和红斑。可以确认，在12天后甚至21天之后，这两个参数都显着改善。进行了两项主要的临床试验，以评估W / O香脂在生殖器部位受刺激的皮肤上的保护和再生特性的安全性和有效性。因此，在一项开放标签的4周临床研究中，招募了29名儿童（男14名，女15名，年龄：15.5±7.8个月）。至少在换尿布后或需要时，在一次性尿布下面的区域使用香脂。此外，在第二项开放式，多中心研究中，纳入了43名女性（平均年龄：46.2±16.9），其易受肛门外生殖器区域皮肤刺激的影响。该产品每天使用4周，每次1-2次。在这两项研究中，参与者和从业人员都对香脂的皮肤耐受性，适用性，香气，可涂抹性和可去除性进行了评估，主要评价为良好或什至非常好，对皮肤的保湿，保护和再生也做出了积极评价。研究证实，新开发的W / O香脂具有极好的耐受性，并且易于去除。同时，可以观察到关于再生和保护功效的优异性能，而在任何时候都没有任何不希望的影响。

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