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首页> 外文期刊>Clinical ophthalmology >Revisiting keratoconus diagnosis and progression classification based on evaluation of corneal asymmetry indices, derived from Scheimpflug imaging in keratoconic and suspect cases
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Revisiting keratoconus diagnosis and progression classification based on evaluation of corneal asymmetry indices, derived from Scheimpflug imaging in keratoconic and suspect cases

机译：基于Scheimpflug成像的圆锥角膜和疑似病例的角膜不对称指数评估，重新探讨圆锥角膜的诊断和进展分类

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Purpose: To survey the standard keratoconus grading scale (Pentacam?-derived Amsler–Krumeich stages) compared to corneal irregularity indices and best spectacle-corrected distance visual acuity (CDVA). Patients and methods: Two-hundred and twelve keratoconus cases were evaluated for keratoconus grading, anterior surface irregularity indices (measured by Pentacam imaging), and subjective refraction (measured by CDVA). The correlations between CDVA, keratometry, and the Scheimpflug keratoconus grading and the seven anterior surface Pentacam-derived topometric indices – index of surface variance, index of vertical asymmetry, keratoconus index, central keratoconus index, index of height asymmetry, index of height decentration, and index of minimum radius of curvature – were analyzed using paired two-tailed t-tests, coefficient of determination (r2), and trendline linearity. Results: The average ± standard deviation CDVA (expressed decimally) was 0.626 ± 0.244 for all eyes (range 0.10–1.00). The average flat meridian keratometry was (K1) 46.7 ± 5.89 D; the average steep keratometry (K2) was 51.05 ± 6.59 D. The index of surface variance and the index of height decentration had the strongest correlation with topographic keratoconus grading (P< 0.001). CDVA and keratometry correlated poorly with keratoconus severity. Conclusion: It is reported here for the first time that the index of surface variance and the index of height decentration may be the most sensitive and specific criteria in the diagnosis, progression, and surgical follow-up of keratoconus. The classification proposed herein may present a novel benchmark in clinical work and future studies.
机译：目的：与圆锥角膜不规则指数和最佳眼镜矫正远视力（CDVA）相比，调查标准圆锥角膜分级量表（Pentacam？衍生的Amsler-Krumeich分期）。患者和方法：对圆锥角膜分级，前表面不规则指数（通过Pentacam成像测量）和主观屈光度（通过CDVA测量）分别评估了圆锥角膜分级331例。 CDVA，角膜曲率和Scheimpflug圆锥角膜分级与七个前Pentacam衍生的拓扑指数之间的相关性-表面变异指数，垂直不对称指数，圆锥角膜指数，中央圆锥角膜指数，身高不对称指数，身高分散指数，最小曲率半径和指数–使用成对的双尾t检验，确定系数（r2）和趋势线线性进行了分析。结果：所有眼睛（范围0.10–1.00）的平均±标准差CDVA（十进制表示）为0.626±0.244。经络平均平角测量值为（K1）46.7±5.89 D;平均陡角计（K2）为51.05±6.59D。表面变化指数和高度偏心指数与圆锥角膜地形分级之间的相关性最强（P <0.001）。 CDVA和角膜测量与圆锥角膜严重程度的相关性很差。结论：这是首次报道表面变异指数和高度偏低指数可能是圆锥角膜的诊断，进展和手术随访中最敏感，最具体的标准。本文提出的分类可能会在临床工作和未来研究中提出新的基准。

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