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Macular pigment optical density: repeatability, intereye correlation, and effect of ocular dominance

机译：黄斑色素光密度：重复性，眼间相关性和眼优势的影响

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Purpose: To evaluate short-term repeatability, intereye correlation, and effect of ocular dominance on macular pigment optical density (MPOD) measurements obtained using the QuantifEye Heterochromatic Flicker Photometer. Patients and methods: A total of 72 study participants were enrolled in this prospective, cross-sectional study. Participants underwent a comprehensive ocular evaluation, including visual acuity, evaluation of ocular dominance, slit lamp examination, intraocular pressure measurement, and optic nerve head and macula analysis using optical coherence tomography and fundus photography. All study participants after initial training underwent MPOD measurement twice in both eyes in a randomized sequence. The repeatability was tested using Altman and Bland plots for first measurements with the second measurements for right eye and left eye and additionally by grouping eyes as a function of ocular dominance. The Pearson correlation coefficient was performed to assess the intereye correlation of MPOD values. Results: The mean age of study participants was 35.5?years (range 22–68?years). The mean MPOD measurements for OD (right eye) and OS (left eye) were 0.47 and 0.48, respectively, which followed a normal distribution (Shapiro–Wilk test, P =0.6 and 0.2). The 95% limits of agreement of Altman and Bland plots for the first and second measurements were -0.12 to +0.11 and -0.13 to +0.12 for OD and OS, respectively. The correlation coefficient of mean MPOD measurements of OD and OS was r statistic =0.94 (Pearson correlation coefficient P 2 0.89). The 95% limits of agreement of Altman and Bland plots when evaluated by laterality of eye or by ocular dominance were narrow, with limits of agreement ranging from -0.13 to +0.12. Conclusion: The MPOD measurements obtained using the QuantifEye show good short-term repeatability. There is excellent intereye correlation, indicating that the MPOD values of one eye data can predict the fellow eye value with 89% accuracy. The ocular dominance had no bearing on the outcome of this psychophysical test in ocular healthy eyes.
机译：目的：评估使用QuantifEye异色闪烁光度计获得的短期可重复性，眼间相关性以及眼优势对黄斑色素光密度（MPOD）测量的影响。患者和方法：共有72名研究参与者参加了这项前瞻性，横断面研究。参加者进行了全面的眼科评估，包括视敏度，眼部优势评估，裂隙灯检查，眼内压测量以及使用光学相干断层扫描和眼底照相的视神经乳头和黄斑分析。初始训练后，所有研究参与者均以随机顺序在两只眼睛中两次进行了MPOD测量。使用奥特曼和布兰德图对第一次测量进行了可重复性测试，对右眼和左眼进行了第二次测量，并根据眼部优势对眼睛进行了分组。进行皮尔逊相关系数以评估MPOD值的眼间相关性。结果：研究参与者的平均年龄为35.5岁（22-68岁）。 OD（右眼）和OS（左眼）的平均MPOD值分别为0.47和0.48，服从正态分布（Shapiro-Wilk检验，P = 0.6和0.2）。第一次和第二次测量的Altman和Bland图的一致性的95％限制是，OD和OS分别为-0.12至+0.11和-0.13至+0.12。 OD和OS的平均MPOD测量值的相关系数为r统计量= 0.94（Pearson相关系数P 2 0.89）。当通过眼睛的侧向度或眼部优势度评估时，Altman和Bland图的95％一致性限制较窄，一致性限制范围为-0.13至+0.12。结论：使用QuantifEye获得的MPOD测量值显示出良好的短期可重复性。极好的眼间相关性，表明一只眼睛数据的MPOD值可以89％的精度预测同一个眼睛的值。在眼睛健康的眼睛中，眼睛的优势与这种心理物理测试的结果无关。

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