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首页> 外文期刊>Cogent Environmental Science >Coral-associated bacterial extracts inhibit cellular NF-κB pathway
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Coral-associated bacterial extracts inhibit cellular NF-κB pathway

机译：珊瑚相关细菌提取物抑制细胞NF-κB途径

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AbstractMarine natural products have recently been recognized as a promising source of NF-κB inhibitors. In this study, extracts of bacterial isolates from the coral Favis sp. were screened for NF-κB modulatory capability using an NF-κB luciferase reporter gene assay. The bacterial extracts had variable effects on NF-κB activity: from the 39 extracts tested, only one exhibited significant NF-κB inhibition and two caused NF-κB up regulation. In addition, we showed that coral bacteria New-33 extract inhibits NF-κB alternative pathway subunits in a non-cytotoxic manner. HPLC analysis confirmed the presence of a low molecular mass compound and NCBI megaBLAST revealed that the New-33 16S rRNA gene sequences are similar to Vibrio mediterranei. This specific modulation of the NF-κB by alternative pathway could contribute to therapeutic implications and also raises questions about host-symbiont interaction in the marine environment.
机译：摘要海洋天然产物最近被认为是有希望的NF-κB抑制剂来源。在这项研究中，从珊瑚Favis sp。中分离出细菌。使用NF-κB荧光素酶报告基因检测筛选NF-κB调节能力。细菌提取物对NF-κB活性具有可变影响：在测试的39种提取物中，只有一种表现出显着的NF-κB抑制作用，另外两种引起NF-κB上调。此外，我们显示珊瑚细菌New-33提取物以非细胞毒性方式抑制NF-κB替代途径亚基。 HPLC分析证实了低分子量化合物的存在，NCBI megaBLAST揭示了New-33 16S rRNA基因序列与地中海弧菌相似。替代途径对NF-κB的这种特殊调节可能有助于治疗，并引起有关海洋环境中宿主-共生体相互作用的问题。

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