Giant cell granulomas (GCGs) of the jaws are lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. Histologically, both peripheral and central giant cell granuloma (CGCG) are characterized by the presence of numerous multinucleated giant cells (MGCs) in a prominent fibrous stroma. CGCG are further categorized into aggressive and non aggressive variant. The present case highlights the perplexity in diagnosing CGCGs which are aggressive in nature due to its close proximity with respect to pathology, behaviour and prognosis from giant cell tumors (GCT). The recurrent nature of the present case and the extensive destruction caused in the hard and soft tissues convinces us the need of exploring the possibilities of the so called true ‘tumors’ (giant cell tumors) having a definitive presence in the jaws.
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