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首页> 外文期刊>Clinical, Cosmetic and Investigational Dermatology >Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth
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Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth

机译：含成纤维细胞生长因子2的达肝素/鱼精蛋白纳米颗粒对头发生长的增强作用

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Purpose: Although treatments for alopecia are in high demand, not all treatments are safe and reliable. Dalteparin/protamine nanoparticles (D/P NPs) can effectively carry growth factors (GFs) such as fibroblast GF (FGF)-2. The purpose of this study was to identify the effects of FGF-2-containing D/P NPs (FGF-2&D/P NPs) on hair growth. Patients and methods: In this study, the participants were 12 volunteers with thin hair. One milliliter of FGF-2 (100 ng/mL) and D/P NPs (56 μg/mL) was applied and massaged on the skin of the scalp by the participants twice a day. They were evaluated for 6?months. Participants were photographed using a digital camera for general observation and a hair diagnosis system for measuring hair diameter. Results: The mean diameter of the hairs was significantly higher following the application of FGF-2&D/P NPs for 6?months. Objective improvements in thin hair were observed in two cases. Nine participants experienced greater bounce and hair resilience. Conclusion: The transdermal application of FGF-2&D/P NPs to the scalp can be used as a new treatment for alopecia.
机译：目的：尽管对脱发的治疗需求很高，但并非所有治疗都是安全可靠的。 Dalteparin /鱼精蛋白纳米颗粒（D / P NPs）可有效携带生长因子（GFs），例如成纤维细胞GF（FGF）-2。这项研究的目的是确定含有FGF-2的D / P NP（FGF-2＆D / P NP）对头发生长的影响。患者和方法：在这项研究中，参与者是12名薄发志愿者。参与者每天两次将一毫升FGF-2（100 ng / mL）和D / P NPs（56μg/ mL）按摩在头皮皮肤上。他们接受了6个月的评估。使用数码相机对参与者进行拍照以进行一般观察，并使用头发诊断系统对头发直径进行测量。结果：应用FGF-2＆D / P NPs 6个月后，头发的平均直径显着增加。在两种情况下，客观地观察到了稀疏的发质。九名参与者的弹跳和头发弹性更好。结论：FGF-2＆D / P NPs经皮应用在头皮上可作为脱发的新疗法。

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