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Bone Mineral Density in Children with GH Deficiency

机译：生长激素缺乏症儿童的骨矿物质密度

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The bone mineral density (BMD) of the 2nd metacarpal bone of the left hand was measured in 14 children with complete GH deficiency (CGHD) and 21 children with partial GH deficiency (PGHD) by the digital image processing (DIP) method. In the pretreatment patients, mean BMD in CGHD was significantly lower than that in normal children. The BMD standard deviation (SD) score in the patients with CGHD who had started the GH treatment before 10 years of age increased by approximately 1.5 SD during GH treatment, while that in the patients with PGHD did not change significantly. Since BMD did not show a pubertal increase in the patients who received combined GH and LHRH analog treatment, their BMD SD score decreased by approximately 1.5 SD. The data demonstrate that GH influences BMD, and the level of BMD in patients with GHD should be followed in a longitudinal observation.
机译：通过数字图像处理（DIP）方法对14例完全GH缺乏（CGHD）儿童和21例部分GH缺乏（PGHD）儿童测量了左手第二掌骨的骨矿物质密度（BMD）。在预处理患者中，CGHD中的平均BMD显着低于正常儿童。在10岁之前开始进行GH治疗的CGHD患者的BMD标准差（SD）评分在GH治疗期间增加了约1.5 SD，而PGHD患者的BMD标准差没有明显变化。由于接受GH和LHRH类似物联合治疗的患者的BMD未显示青春期增加，因此其BMD SD评分降低了约1.5 SD。数据表明GH影响BMD，在纵向观察中应遵循GHD患者的BMD水平。

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