• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical Pediatric Endocrinology >Preventive Effect of Long-Term GH Therapy on Cardiovascular Risk Factors in Patients with GH Deficiency
【24h】

Preventive Effect of Long-Term GH Therapy on Cardiovascular Risk Factors in Patients with GH Deficiency

机译：长期GH疗法对GH缺乏症患者心血管危险因素的预防作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

GH has some influence on cardiovascular risk factors. The effects of long-term GH replacement therapy on hemostatic and lipid parameters were examined in pediatric patients with GH deficiency. Hemostatic markers (fibrinogen, D-dimer, TAT, tPA-PAI, and PIC) and lipid parameters (total cholesterol, HDL-cholesterol, LDL-cholesterol, and Lp (a)) were evaluated in 30 pediatric patients before and during GH therapy. They were treated with recombinant GH (0.5 I.U. /kg/week) for 2.4±0.5 years. Eight patients had complete GH deficiency (aged 10.6±3.3 years; 5 males and 3 females), including 4 with craniopharyngioma (13.7±5.4 years; 2 males and 2 females), and 22 had partial GH deficiency (10.6±3.3 years; 11 males and 11 females). Statistical analysis was done with the Mann-Whitney nonparametric rank sum test. Plasma D-dimer (p<0.01) and fibrinogen (p<0.01) decreased after 2.4±0.5 years of GH treatment. There were no significant changes in total cholesterol, triglycerides, or HDL-and LDL-cholesterol, but there was an increase in lipoprotein (a) (p<0.02) and insulin (p<0.02). The free T3 (p<0.0003) and TSH (p<0.003) levels decreased, but there was no effect on free T4or the body mass index. Decreased hemostatic activity is a beneficial effect of GH on cardiovascular risk factors. Ceasing GH therapy by 20 years of age on completion of growth might lead to the onset of cardiovascular disease in adult life, so continuing GH therapy beyond this age may be necessary.
机译：GH对心血管危险因素有一定影响。检查了长期GH替代疗法对GH缺乏患儿的止血和血脂参数的影响。在GH治疗之前和期间，对30名儿科患者进行了止血指标（纤维蛋白原，D-二聚体，TAT，tPA-PAI和PIC）和脂质参数（总胆固醇，HDL-胆固醇，LDL-胆固醇和Lp（a））的评估。 。他们接受重组GH（0.5 I.U./kg/周）治疗2.4±0.5年。 8例完全GH缺乏（10.6±3.3岁; 5例男性和3例女性），包括4例颅咽管瘤（13.7±5.4岁; 2例男性和2例女性）; 22例部分GH缺乏（10.6±3.3岁; 11例）男性和11位女性）。用Mann-Whitney非参数秩和检验进行统计分析。 GH治疗2.4±0.5年后，血浆D-二聚体（p <0.01）和纤维蛋白原（p <0.01）降低。总胆固醇，甘油三酸酯或HDL和LDL-胆固醇没有明显变化，但脂蛋白（a）（p <0.02）和胰岛素（p <0.02）有所增加。游离T3（p <0.0003）和TSH（p <0.003）水平降低，但对游离T4或体重指数没有影响。止血活性降低是GH对心血管危险因素的有益作用。在生长完成后20岁时停止GH治疗可能会导致成年人罹患心血管疾病，因此可能需要在此年龄之后继续进行GH治疗。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号