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GH Treatment of Children with Chronic Renal Insufficiency: A Japanese Clinical Trial

机译：GH治疗儿童慢性肾功能不全：日本临床试验

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The 1-and 2-year effects of recombinant human GH (rhGH) were evaluated in 80 Japanese children with chronic renal insufficiency (CRI): 32 were on dialysis and 48 were receiving predialysis treatment. The patients were divided into two groups: one was treated with rhGH 0.5 IU/kg/week and the other with rhGH 1.0 IU/kg/week. Mean height velocity (HV) in predialysis children during the year preceding rhGH treatment and during the first and the second year of treatment was 4.4±1.5cm/year, 7.8±1.6 cm/year, and 6.4±2.0 cm/year, respectively, in those treated with rhGH 0.5 IU/kg/week and 4.8±1.4 cm/year, 8.9±2.2 cm/year, and 6.2±1.7 cm/year, respectively, in those treated with rhGH 1.0 IU/kg/week. HV increased significantly during treatment with both rhGH doses compared to pretreatment HV, but the difference between the treatment groups was not significant. In dialysis children, HV did not increase significantly during treatment with 0.5 IU/kg/week of rhGH, but in-creased significantly from 3.6±2.4 cm/year during pretreatment to 7.2±2.2 cm/year and 6.0±1.6cm/year after treatment with 1.0 IU/kg/week of rhGH for one and two years, respectively. From these results the recommended rhGH dose for children on dialysis and predialysis children receiving a supportive treatment is 1.0 IU/kg/week and 0.5 IU/kg/week, respectively.
机译：在80例日本慢性肾功能不全（CRI）儿童中评估了重组人GH（rhGH）的1年和2年效果：32例接受透析，48例接受透析前治疗。将患者分为两组：一组用rhGH 0.5 IU / kg /周治疗，另一组用rhGH 1.0 IU / kg /周治疗。在rhGH治疗之前的一年以及治疗的第一年和第二年，透析前儿童的平均身高速度（HV）分别为4.4±1.5cm /年，7.8±1.6cm /年和6.4±2.0cm /年。 rhGH 0.5 IU / kg /周和4.8±1.4 cm /年，8.9±2.2 cm /年和6.2±1.7 cm /年治疗的rhGH 1.0 IU / kg /周的患者。与预处理HV相比，两种rhGH剂量在治疗期间HV均显着增加，但治疗组之间的差异并不显着。在透析儿童中，以0.5 IU / kg /周的rhGH治疗期间，HV并未显着增加，但从治疗前的3.6±2.4 cm /年显着增加至治疗后的7.2±2.2 cm /年和6.0±1.6cm /年。用1.0 IU / kg /周的rhGH分别治疗一年和两年。从这些结果中，接受支持治疗的透析儿童和透析前儿童的建议rhGH剂量分别为1.0 IU / kg /周和0.5 IU / kg /周。

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