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首页> 外文期刊>Clinical Pediatric Endocrinology >Growth Hormone and IGF-I Secretion in Girls with Precocious Puberty Treated with Depot GnRH Analogues
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Growth Hormone and IGF-I Secretion in Girls with Precocious Puberty Treated with Depot GnRH Analogues

机译：用GnRH库类似物治疗性早熟女孩的生长激素和IGF-I分泌

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In order to assess growth, growth hormone and IGF-I levels in girls treated with long-acting GnRH analogue (D-TRP-6-analogue), we evaluated 14 girls with idiopathic central precocious puberty. The age at the beginning of pubertal signs was 2.1 to 6.8 years; the diagnosis of GnRH-dependent precocious puberty was confirmed by a pubertal pattern of gonadotrophin response to an exogenous bolus of 2.5 μg/kg of synthetic gonadorelin hydrocloride. Evaluating growth velocity during 24-mon therapy with the analogue, it was possible to distinguish a group of 6 girls who grew less than 4 cm/year (group A) and a group of 8 girls whose growth velocity was greater than 4 cm/year (group B). Growth hormone secretion was assessed by clonidine (0.15 mg/m2 orally) and pyridostigmine (60 mg orally) plus GHRH (after 60 min). Physiological GH secretion was evaluated by measuring GH in blood sampled every 30 min for 10 h from 2200 to 0800. No significant difference was observed in 10-h mean nocturnal secretion between group-A and group-B girls. Also stimulated GH levels did not differ between the two groups. Four girls (28.6%) had subnormal responses to stimulation tests peak <10 μg/L after clonidine and 20 μg/L after pyridostigmine plus GHRH; of these children two belonged to group A and two to group B. Height, growth rate, bone maturation rate and predicted height did not correlate with either spontaneous or stimulated GH levels. IGF-I levels were similar in the two groups; a significant reduction of IGF-I serum levels was observed in both groups after 24 mon of GnRH-analogue therapy. In conclusion, in some children with precocious puberty growth velocity significantly declines after 24 mon of therapy with long-acting GnRH agonists, but spontaneous and stimulated GH and IGF-I secretion is not related to growth velocity.
机译：为了评估用长效GnRH类似物（D-TRP-6-类似物）治疗的女孩的生长，生长激素和IGF-I水平，我们评估了14位患有特发性中枢性性早熟的女孩。青春期征兆开始的年龄为2.1至6.8岁;促性腺激素对2.5μg/ kg合成促性腺激素氢氯吡咯外源性大剂量反应的青春期模式证实了GnRH依赖性早熟的诊断。用类似物评估24个月疗法期间的生长速度，可以区分出一组6名女孩的生长速度小于4厘米/年（A组）和一组8名女孩的生长速度大于4厘米/年（B组）。通过可乐定（口服0.15 mg / m2）和吡啶斯的明（口服60 mg）加GHRH（60分钟后）评估生长激素分泌。通过测量从2200至0800每30分钟采样10小时的血液中的GH来评估生理性GH分泌。A组和B组女孩的10小时平均夜间分泌量没有显着差异。两组之间刺激的GH水平也没有差异。 4名女孩（28.6％）对可乐定的刺激试验反应低于正常，可乐定后峰值<10μg/ L，吡ido斯的明+ GHRH后峰值<20μg/ L;这些孩子中有两个属于A组，两个属于B组。身高，生长速度，骨骼成熟率和预测身高与自发或刺激的GH水平无关。两组的IGF-I水平相似。 GnRH-类似物治疗24个月后，两组均观察到IGF-1血清水平显着降低。总之，在一些早熟性青春期儿童中，长效GnRH激动剂治疗24个月后，其生长速度显着下降，但自发和刺激的GH和IGF-I分泌与生长速度无关。

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