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首页> 外文期刊>CBE Life Sciences Education >RNA Secondary Structure Prediction by Using Discrete Mathematics: An Interdisciplinary Research Experience for Undergraduate Students
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RNA Secondary Structure Prediction by Using Discrete Mathematics: An Interdisciplinary Research Experience for Undergraduate Students

机译：使用离散数学预测RNA二级结构：跨学科研究经验的本科生。

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The focus of this Research Experience for Undergraduates (REU) project was on RNA secondary structure prediction by using a lattice walk approach. The lattice walk approach is a combinatorial and computational biology method used to enumerate possible secondary structures and predict RNA secondary structure from RNA sequences. The method uses discrete mathematical techniques and identifies specified base pairs as parameters. The goal of the REU was to introduce upper-level undergraduate students to the principles and challenges of interdisciplinary research in molecular biology and discrete mathematics. At the beginning of the project, students from the biology and mathematics departments of a mid-sized university received instruction on the role of secondary structure in the function of eukaryotic RNAs and RNA viruses, RNA related to combinatorics, and the National Center for Biotechnology Information resources. The student research projects focused on RNA secondary structure prediction on a regulatory region of the yellow fever virus RNA genome and on an untranslated region of an mRNA of a gene associated with the neurological disorder epilepsy. At the end of the project, the REU students gave poster and oral presentations, and they submitted written final project reports to the program director. The outcome of the REU was that the students gained transferable knowledge and skills in bioinformatics and an awareness of the applications of discrete mathematics to biological research problems.
机译：这项针对大学生的研究经验（REU）项目的重点是使用晶格步移方法​​进行RNA二级结构预测。晶格步移法是一种组合和计算生物学方法，用于枚举可能的二级结构并根据RNA序列预测RNA二级结构。该方法使用离散数学技术，并将指定的碱基对识别为参数。 REU的目标是向高年级本科生介绍分子生物学和离散数学跨学科研究的原理和挑战。在项目开始之初，一所中型大学的生物学和数学系的学生接受了有关二级结构在真核RNA和RNA病毒，与组合物有关的RNA的功能中的作用以及国家生物技术信息中心的指导。资源。该学生的研究项目专注于黄热病病毒RNA基因组调控区域和与神经性癫痫症相关的基因mRNA的非翻译区域的RNA二级结构预测。在项目结束时，REU的学生作了海报和口头报告，并向项目主管提交了书面的最终项目报告。 REU的结果是，学生获得了生物信息学方面可转让的知识和技能，并且意识到了离散数学在生物学研究问题中的应用。

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