• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical Pediatric Endocrinology >A Report of Three Girls with Antithyroid Drug-Induced Agranulocytosis; Retrospective Analysis of 18 Cases Aged 15 Years or Younger Reported between 1995 and 2009
【24h】

A Report of Three Girls with Antithyroid Drug-Induced Agranulocytosis; Retrospective Analysis of 18 Cases Aged 15 Years or Younger Reported between 1995 and 2009

机译：三例抗甲状腺药物致粒细胞缺乏症的报告;回顾性分析1995年至2009年报告的15岁以下15例

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Agranulocytosis is an extremely serious, although rare, adverse effect of antithyroid drugs (ATDs), including methimazole (MMI) and propylthiouracil (PTU), in children and adolescents. There are few reports about the characteristics of ATD-induced agranulocytosis in Japanese children and adolescents. This report presents the cases of three girls with ATD-induced agranulocytosis and a retrospective analysis of 18 patients with ATD-induced agranulocytosis, whose cases had been referred to the drug manufacturer, Chugai Pharmaceutical Co., Ltd. Our 3 patients, ranging in age from 12 to 14 yr, developed ATD-induced agranulocytosis between the 15th and 57th day of ATD treatment for hyperthyroidism. Fever and sore throat were the earliest symptoms of agranulocytosis. The patients were rescued by ceasing ATD therapy and administering antibiotics, potassium iodide, glucocorticoid, immunoglobulin and granulocyte colony-stimulating factor (G-CSF). We retrospectively analyzed 18 cases of ATD-induced agranulocytosis treated with MMI in 16 cases and PTU in 2 cases. Twelve patients were treated with 20–45 mg/d MMI. Agranulocytosis developed between the 15th and 1,344th day of therapy. In conclusion, considering the risk of ATD-induced agranulocytosis, we recommend low-dose MMI therapy for treatment of Graves’ disease.
机译：粒细胞缺乏症是抗甲状腺药物（ATD）（包括甲巯咪唑（MMI）和丙硫氧嘧啶（PTU））对儿童和青少年的一种极为严重的副作用，尽管这种情况很少见。关于ATD诱导的日本儿童和青少年粒细胞缺乏症的特征的报道很少。本报告介绍了三名患有ATD引起的粒细胞缺乏症的女孩的病例，并对18例ATD引起的粒细胞缺乏症的患者进行了回顾性分析，其病例已转交给药物制造商中外制药有限公司。我们的3例患者年龄不同从12到14岁，在甲亢的ATD治疗第15天至第57天之间出现了ATD诱导的粒细胞缺乏症。发烧和咽喉痛是粒细胞缺乏症的最早症状。通过停止ATD治疗并使用抗生素，碘化钾，糖皮质激素，免疫球蛋白和粒细胞集落刺激因子（G-CSF）挽救了患者。我们回顾性分析了18例ATD引起的粒细胞缺乏症，MMI治疗16例，PTU治疗2例。 12名患者接受了20-45 mg / d MMI的治疗。在治疗的第15天至第1344天之间出现粒细胞缺乏症。总之，考虑到ATD引起的粒细胞缺乏症的风险，我们建议使用小剂量MMI治疗Graves病。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号