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首页> 外文期刊>Clinical Pediatric Endocrinology >Insulin Resistance during Puberty in Non-obese Japanese Children
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Insulin Resistance during Puberty in Non-obese Japanese Children

机译：非肥胖日本儿童青春期的胰岛素抵抗

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We examined whether non-obese Japanese children without diabetes exhibited insulin resistance during puberty. The study subjects were 201 Japanese school students, consisting 95 males and 106 females, aged 11.5 ± 2.6 yr. None of the subjects were obese, with the mean percent of overweight being 0.7 ± 10.5%, or had diabetes at the time of the study. Overnight fasting plasma values of insulin (FIRI) and HOMA-R were measured, with concomitant measurement of the plasma glucose (FPG) levels. The mean FPG, FIRI and HOMA-R values were 89.6 ± 7.3 (70–109) mg/dl, 9.0 ± 3.6 (1.7–24.4) μU/ml and 2.0 ± 0.9 (0.3–5.2), respectively. The mean FIRI value was significantly higher in females than in males (8.3 ± 3.4 vs. 9.6 ± 3.7 μU/ml, p=0.0060). The FIRI and HOMA-R values of the pubertal students were significantly higher compared with those of the prepubertal students (FIRI, 10.0 ± 3.4 vs. 6.5 ± 2.8 μU/ml; HOMA-R, 2.3 ± 0.8 vs. 1.4 ± 0.7; p<0.0001 for both). Similar trends were observed between the two genders. The mean FIRI levels and HOMA-R values were positively correlated with age (FIRI, r=0.280, p<0.0001; HOMA-R, r=0.300, p<0.0001). In conclusion, we demonstrated that the FIRI and HOMA-R values were significantly associated with pubertal development in non-obese Japanese children without diabetes, consistent with the results of studies in white and black children.
机译：我们检查了没有肥胖的日本无糖尿病儿童在青春期是否表现出胰岛素抵抗。研究对象为201名日本在校学生，包括95名男性和106名女性，年龄为11.5±2.6岁。没有受试者是肥胖的，平均超重百分比为0.7±10.5％，或者在研究时患有糖尿病。过夜空腹血浆胰岛素（FIRI）和HOMA-R的血浆值进行了测量，并同时测定了血浆葡萄糖（FPG）的水平。 FPG，FIRI和HOMA-R的平均值分别为89.6±7.3（70-109）mg / dl，9.0±3.6（1.7-24.4）μU/ ml和2.0±0.9（0.3-5.2）。女性的平均FIRI值明显高于男性（8.3±3.4 vs. 9.6±3.7μU/ ml，p = 0.0060）。青春期学生的FIRI和HOMA-R值明显高于青春期前学生（FIRI，10.0±3.4 vs. 6.5±2.8μU/ ml; HOMA-R，2.3±0.8 vs. 1.4±0.7; p两者均<0.0001）。两种性别之间也观察到类似趋势。 FIRI平均水平和HOMA-R值与年龄呈正相关（FIRI，r = 0.280，p <0.0001; HOMA-R，r = 0.300，p <0.0001）。总之，我们证明了FIRI和HOMA-R值与非肥胖日本无糖尿病儿童的青春期发育显着相关，这与白人和黑人儿童的研究结果一致。

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