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Animal Model of Uterine Adenomyosis: Induction of the Lesion in Rats by Ectopic Pituitary Isografting

机译:子宫腺肌病的动物模型:异位垂体同种异体移植诱导大鼠损伤

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Adenomyosisisabenignpathologicdisorderoftheuterineendometrialtissueswherebyendometrialcomponents,suchasglandsandstroma,invadethemyometrium.TransplantationofasingleanteriorpituitaryglandintotheuterinelumeninducedadenomyosisinsixofeightWistarrats12monthsafterthegrafting.Adenomyoticchangeswerenotobservedinsixsham-operatedcontrolrats.Electronmicroscopicobservationsindicatedthatcellsoftheinnerlayerofthemyometriumwerereducedinsizeandirregularlyshapedintheareasbearingadenomyoticchanges.Inpituitary-graftedrats,healthycorporalutearemainedintheovaries,whereascontrolratshaddegeneratingovaries.Thesefindingsareconsistentwiththeresultsofpituitary-graftedmicereportedpreviouslyandsupportourassertionthatahormonalmilieuinducedbypituitarygraftingisfavorablefordevelopmentofuterineadenomyosis.
机译:Adenomyosisisabenignpathologicdisorderoftheuterineendometrialtissueswherebyendometrialcomponents,suchasglandsandstroma,invadethemyometrium.TransplantationofasingleanteriorpituitaryglandintotheuterinelumeninducedadenomyosisinsixofeightWistarrats12monthsafterthegrafting.Adenomyoticchangeswerenotobservedinsixsham-operatedcontrolrats.Electronmicroscopicobservationsindicatedthatcellsoftheinnerlayerofthemyometriumwerereducedinsizeandirregularlyshapedintheareasbearingadenomyoticchanges.Inpituitary-graftedrats,healthycorporalutearemainedintheovaries,whereascontrolratshaddegeneratingovaries.Thesefindingsareconsistentwiththeresultsofpituitary-graftedmicereportedpreviouslyandsupportourassertionthatahormonalmilieuinducedbypituitarygraftingisfavorablefordevelopmentofuterineadenomyosis。

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