Evaluation of Cynomolgus (Macaca fascicularis) and Rhesus (Macaca mulatta) Monkeys as Experimental Models of Acute Q Fever after Aerosol Exposure to Phase-I Coxiella burnetii

Waag David M.; Byrne W. Russell; Estep Jim; Gibbs Paul; M. Pitt M. Louise

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Evaluation of Cynomolgus (Macaca fascicularis) and Rhesus (Macaca mulatta) Monkeys as Experimental Models of Acute Q Fever after Aerosol Exposure to Phase-I Coxiella burnetii

机译：评价食蟹猴（猕猴）和恒河猴（猕猴）作为气溶胶暴露于第一阶段的柯氏杆菌后急性Q发实验模型

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BackgroundandPurpose:Qfeverisadiseaseofhumans.Vaccinestopreventthisdiseasehavedemonstratedefficacyinrodentsandmustalsobeevaluatedforefficacyinanonhumanprimatemodel.Preliminarytovaccineefficacyexperiments,cynomolgusandrhesusmonkeyswereevaluatedassuitableexperimentalmodelsofacuteQfever.brxmlns="http://pub2web.metastore.ingenta.coms/"/brMethods:Bothspeciesofmonkeyswerechallengedwithaerosolized105virulentphase-ICoxiellaburnetiiHenzerlingstrain,andclinicalandserologicresponsesweredetermined.brxmlns="http://pub2web.metastore.ingenta.coms/"/brResults:Radiographicchangeswereobservedinsevenofeightmonkeysofbothspecies;however,changesincynomolgusmonkeystendedtobemoresignificant.Between7and10daysafterchallenge,allrhesusmonkeysand88%ofcynomolgusmonkeyswerebacteremic.SequentialincreasesinantibodyresponsestoC.burnetiiphase-Iandphase-IIwholecellsandphase-Ilipopolysaccharidewereobservedinbothspecies.Althoughthemaximalrectaltemperatureincreasewassimilarinbothspecies,durationoffeverwasslightlylongerinrhesusmonkeys.ClinicalfeaturesweresimilartothosedescribedinhumanacuteQfeverpatients.brxmlns="http://pub2web.metastore.ingenta.coms/"/brConclusions:Onthebasisofthemorepronouncedradiographicchangesincynomolgusmonkeys,wefavoruseofthisspeciesforfuturestudiesofvaccineefficacy.

机译：BackgroundandPurpose：Qfeverisadiseaseofhumans.Vaccinestopreventthisdiseasehavedemonstratedefficacyinrodentsandmustalsobeevaluatedforefficacyinanonhumanprimatemodel.Preliminarytovaccineefficacyexperiments，cynomolgusandrhesusmonkeyswereevaluatedassuitableexperimentalmodelsofacuteQfever 方法：Bothspeciesofmonkeyswerechallengedwithaerosolized105virulentphase-ICoxiellaburnetiiHenzerlingstrain，andclinicalandserologicresponsesweredetermined 结果：Radiographicchangeswereobservedinsevenofeightmonkeysofbothspecies;然而，changesincynomolgusmonkeystendedtobemoresignificant.Between7and10daysafterchallenge，allrhesusmonkeysand88％ofcynomolgusmonkeyswerebacteremic.SequentialincreasesinantibodyresponsestoC.burnetiiphase-Iandphase-IIwholecellsandphase-Ilipopolysaccharidewereobservedinbothspecies.Althoughthemaximalrectaltemperatureincreasewassimilarinbothspecies，durationoffeverwasslightl 结论：基于更多的发音放射线变化性无糖猴子，我们喜欢使用这种物种。

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《Comparative Medicine》 |1999年第6期|共页
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Waag David M.; Byrne W. Russell; Estep Jim; Gibbs Paul; M. Pitt M. Louise;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Evaluation of cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta) monkeys as experimental models of acute Q fever after aerosol exposure to phase-I Coxiella burnetii [J] . Waag DM, Byrne WR, Estep J, Laboratory Animal Science . 1999,第6期

机译：食蟹猴（Coxiella burnetii）气溶胶暴露后，食蟹猕猴和恒河猴（猕猴）作为急性Q发实验模型的评价
2. Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey ( Macaca fascicularis) and rhesus monkeys ( Macaca mulatta) nesthetized with ketamine hydrochloride [J] . Son Y., Yoon S. B., Kim J. S. Human gene therapy . 2019,第11期

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3. Age-related nomograms of serum anti-Mullerian hormone levels in female monkeys: Comparison of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) monkeys [J] . Long Hui, Wang Yan, Wang Li, General and comparative endocrinology . 2018,第期

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4. Biomechanics of the Vertebral Column and Internal Organ Response to Seated Spinal Impact in the Rhesus Monkey (Macaca Mulatta) [C] . L. E. Kazarian, J. W. Hahn, H. E. von Gierke Stapp Car Crash Conference . 2009

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5. Pathogenesis of acquired cytopenias in simian betaretrovirus (SRV) infection of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques [D] . Montiel, Nestor A. 2008

机译：猕猴（猕猴）和猕猴（猕猴）猕猴猿猴逆转录病毒（SRV）感染中获得性血细胞减少的发病机理
6. Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride [O] . Bon-Sang Koo, Dong-Ho Lee, Philyong Kang, 2019

机译：盐酸氯胺酮麻醉的食蟹猕猴和猕猴的血液学和生化指标参考值
7. Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride [O] . Bon-Sang Koo, Dong-Ho Lee, Philyong Kang, 2019

机译：用氯胺酮麻醉的盐酸盐猴（猕猴属植物）和恒河猴（Macaca Mulatta）的血液学和生化参数的参考值

Evaluation of Cynomolgus (Macaca fascicularis) and Rhesus (Macaca mulatta) Monkeys as Experimental Models of Acute Q Fever after Aerosol Exposure to Phase-I Coxiella burnetii

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