Evaluation of Helicobacter hepaticus Bacterial Shedding in Fostered and Sex-Segregated C57BL/6 Mice

Crisler-Roberts Robin; Ge Zhongming; Kearney Michael T.; Singletary Kem B.; Fox James G.; Roberts Christopher S.; Baker David G.

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Evaluation of Helicobacter hepaticus Bacterial Shedding in Fostered and Sex-Segregated C57BL/6 Mice

机译：寄养和性别隔离的C57BL / 6小鼠肝细菌性细菌脱落的评估

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NeonatalfosteringhasbeenevaluatedasameansofeliminatingHelicobacterhepaticusinfectioninlaboratorymousecolonies.Thepurposeofthepresentstudywastoevaluatecross-fosteringofneonatalC57BL/6pupsfromexperimentallyinfecteddamsaftermale-absentparturitionandtodeterminetheeffectsofsexandhousingstrategyonH.hepaticuspopulations.Approximately20C57BL/6mice(age,1to4days)werefostereddaily.Inallfosteredmice,fecalsamplescollectedat21and42daysofageandcecalsamplescollectedat42daysofagetestednegativeforH.hepaticusbypolymerasechainreactionanalysis.OurresultsdemonstratethatremovalofthemalepriortoparturitionextendsthefosteringperiodtoyieldHelicobacter-freemice.Inasecondexperiment,theeffectsoftimeofinfection,housingstrategy,andsexonfecalH.hepaticussheddingandcecalcolonizationwereevaluated.Neithertimenorhousingstrategyaffectedbacterialshedding.Incontrast,fecalandcecalbacterialloadswerehigherinmalemiceversusfemalemice.Anovelpredictivealgorithmwasdevelopedtopredictcecalbacterialcolonizationlevelsinlightoffecalbacterialloads.OurfindingslikelywillproveusefulinHelicobactereradicationeffortsandinstudiesdesignedtofurtherelucidatetheroleofH.hepaticusindisease.

机译：NeonatalfosteringhasbeenevaluatedasameansofeliminatingHelicobacterhepaticusinfectioninlaboratorymousecolonies.Thepurposeofthepresentstudywastoevaluatecross-fosteringofneonatalC57BL / 6pupsfromexperimentallyinfecteddamsaftermale-absentparturitionandtodeterminetheeffectsofsexandhousingstrategyonH.hepaticuspopulations.Approximately20C57BL / 6mice（年龄，1to4days）werefostereddaily.Inallfosteredmice，fecalsamplescollectedat21and42daysofageandcecalsamplescollectedat42daysofagetestednegativeforH.hepaticusbypolymerasechainreactionanalysis.OurresultsdemonstratethatremovalofthemalepriortoparturitionextendsthefosteringperiodtoyieldHelicobacter-freemice.Inasecondexperiment，theeffectsoftimeofinfection，housingstrategy，andsexonfecalH.hepaticussheddingandcecalcolonizationwereevaluated.Neithertimenorhousingstrategyaffectedbacterialshedding.Incontrast，fecalandcecalbacterialloadswerehigherinmalemiceversusfemalemice.Anovelpredictivealgorithmwasdevelopedtopredictcecalbacterialcolonizationlevelsinlightoffecalbacter我们的研究结果可能会证明在幽门螺杆菌根除工作中的应用以及为进一步阐明肝炎性疾病的透明性而设计的研究很有用。

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《Comparative Medicine》 |2005年第6期|共页
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Crisler-Roberts Robin; Ge Zhongming; Kearney Michael T.; Singletary Kem B.; Fox James G.; Roberts Christopher S.; Baker David G.;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Evaluation of Helicobacter hepaticus bacterial shedding in fostered and sex-segregated C57BL/6 mice [J] . Crisler-Roberts R, Ge Z, Kearney MT, Comparative Medicine . 2005,第6期

机译：在成年和性别隔离的C57BL / 6小鼠中评估肝杆菌的细菌脱落
2. Long-term Colonization Levels of Helicobacter hepaticus in the Cecum of Hepatitis-Prone A/JCr Mice Are Significantly Lower Than Those in Hepatitis-Resistant C57BL/6 Mice [J] . Whary, Mark T., nbsp, Comparative Medicine . 2001,第5期

机译：肝炎-Prone A / JCr小鼠盲肠中长期肝菌的定殖水平明显低于抗肝炎的C57BL / 6小鼠
3. Prevalence of Helicobacter hepaticus, Murine Norovirus, and Pneumocystis carinii and Eradication Efficacy of Cross-Fostering in Genetically Engineered Mice [J] . Su-Cheong YEOM, Sun-A YU, Eun-Young CHOI, Experimental Animals . 2009,第5期

机译：遗传工程小鼠中肝杆菌，鼠诺如病毒和卡氏肺孢子虫的患病率及交叉寄养的根除功效
4. Quantification of inflammation-induced oxidized deoxyguanosine lesion in colon and liver from Helicobacter hepaticus-infected Rag2-deficient mice [C] . Wenjie Ye, Aswin Mangerich, Liang Cui, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：炎症诱导的氧化脱氧胍病病变的结肠杆菌感染肝病感染的RAG2缺陷小鼠
5. Helicobacter hepaticus induced gene dysregulation in mice [D] . Myles, Matthew Howard 2004

机译：肝杆菌引起的小鼠基因失调
6. Intestinal Microbiota Composition of Interleukin-10 Deficient C57BL/6J Mice and Susceptibility to Helicobacter hepaticus-Induced Colitis [O] . Ines Yang, Daniel Eibach, Friederike Kops, -1

机译：白细胞介素10缺陷型C57BL / 6J小鼠的肠道菌群组成和易感性肝炎性结肠炎。
7. Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis. [O] . Ines Yang, Daniel Eibach, Friederike Kops, 2013

机译：白细胞介素-10缺陷型C57BL / 6J小鼠的肠道微生物群组成和对肝螺杆菌诱导的结肠炎的易感性。

Evaluation of Helicobacter hepaticus Bacterial Shedding in Fostered and Sex-Segregated C57BL/6 Mice

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