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首页> 外文期刊>Comparative Medicine >Ulcerative Dermatitis in C57BL/6 Mice Lacking Stearoyl CoA Desaturase 1
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Ulcerative Dermatitis in C57BL/6 Mice Lacking Stearoyl CoA Desaturase 1

机译：缺乏硬脂酰辅酶A去饱和酶1的C57BL / 6小鼠的溃疡性皮肤炎

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Ulcerativedermatitis(UD)isacommoncauseofmorbidityandeuthanasiainmicewithaC57BL/6(B6)background.ThepurposesofthecurrentstudyweretodeterminewhetherUDlesionscouldbereliablyproducedinB6micelackingstearoyl-CoAdesaturase1(SCD1sup#8211;/#8211;/supmice),toascertainwhethertheUDlesionsinSCD1sup#8211;/#8211;/supmiceweresimilartothosefoundinotherB6mice,andtocharacterizethecellinvasionphenotypeofStaphlococcusxylosusculturedfromthelesions.S.xylosusisolatesfromtheenvironmentandhumanskinwereusedascontrols.SCD1sup#8211;/#8211;/sup(n=8pergroup)andnontransgenicB6controlmice(n=22micepooledfrom3groupsthatreceiveddifferentconcentrationsofconjugatedlinoleicacid)werefedstandardrodentchoworasemipurifieddiet(NIHAIN76A)for4wk.SamplesfromotherB6micewithUD(fieldcases;n=7)alsoweresubmittedforhistologyandculture.AlloftheSCD1sup#8211;/#8211;/supmicedevelopedUDlesionsby4wkonNIHAIN76A.NoneofSCD1sup#8211;/#8211;/supfedstandardrodentchowandnoneofthewildtypeB6micefedNIHAIN76AdevelopedUD.Supplementationwithconjugatedlinoleicaciddidnotaffectulcerogenesis.UDlesionsinSCD1sup#8211;/#8211;/supmiceandfieldcasesweregrosslyandhistologicallysimilar.S.xylosuswasisolatedfromSCD1sup#8211;/#8211;/supmicewithUD(71%)andfieldcasesofUD(43%).Theseisolateswerethemostcell-invasive,followedbytheenvironmentalisolate,andfinallythehumanskinisolate.OurresultsprovideabasisforfurtherpathologicandclinicalstudyofUD.
机译：Ulcerativedermatitis（UD）isacommoncauseofmorbidityandeuthanasiainmicewithaC57BL / 6（B6）background.ThepurposesofthecurrentstudyweretodeterminewhetherUDlesionscouldbereliablyproducedinB6micelackingstearoyl CoAdesaturase1（SCD1 ＃8211; /＃8211; 只小鼠），toascertainwhethertheUDlesionsinSCD1 ＃8211; /＃8211; miceweresimilartothosefoundinotherB6mice andtocharacterizethecellinvasionphenotypeofStaphlococcusxylosusculturedfromthelesions.S.xylosusisolatesfromtheenvironmentandhumanskinwereusedascontrols.SCD1 ＃8211; /＃8211; （N = 8pergroup）andnontransgenicB6controlmice（N = 22micepooledfrom3groupsthatreceiveddifferentconcentrationsofconjugatedlinoleicacid）werefedstandardrodentchoworasemipurifieddiet（NIHAIN76A）for4wk.SamplesfromotherB6micewithUD（fieldcases; N = 7）alsoweresubmittedforhistologyandculture.AlloftheSCD1 ＃8211; /＃8211; 小鼠通过4wkonNIHAIN76A开发了UDlesions与共轭亚油酸没有致癌作用。 ，其次是环境隔离物，最后是人类皮肤隔离物。我们的研究结果为UD的进一步病理学和临床研究提供了依据。

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