Effect of Prophylactic Supplementation with Grape Polyphenolics on Endotoxin-Induced Serum Secretory Phospholipase A2 Activity in Rats

Tsao Francis HC; Culver Bryan J; Pierre Joseph F; Shanmuganayagam Dhanansayan; Patten Calvin C; Meyer Keith C

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Effect of Prophylactic Supplementation with Grape Polyphenolics on Endotoxin-Induced Serum Secretory Phospholipase A2 Activity in Rats

机译：预防性补充葡萄多酚对内毒素诱导的大鼠血清分泌磷脂酶A2活性的影响

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Thisstudyinvestigatedwhetherdietarysupplementationofpolyphenolics-richgrapeextract(GE)couldattenuateendotoxin-inducedserumsecretoryphospholipaseAsub2/sub(sPLAsub2/sub)activity,amodulatorofinflammation.MaleSprague#8211;Dawleyratswerefedacontroldietorthedietsupplementedwithpolyphenolic-richGE(100or300mg/kgdaily)for3wkpriortointraperitonealinjectionof3or15mg/kgLPS.AfluorometricassaywasusedtomeasureserumsPLAsub2/subactivityduringa5-dperiodbeforeandafterLPSinjection.Bodyweight,hematocrit,andserumC-reactiveproteinlevelwerealsomeasured.AdministrationofLPSinducedarapidincreaseinsPLAsub2/subactivity,whichpeaked1to2dafterLPSinjectionandresolvedtonear-baselinevaluesondays4to5.Markeddeclinesinbodyweightandhematocrit,increasesinC-reactiveproteinlevels,andeffectsonhealthstatusalsooccurred.GEsupplementationsignificantlyattenuatedtheLPS-inducedincreaseinsPLAsub2/subactivityanddeclineinhematocrit,butitseffectsonthelossofbodyweightandC-reactiveproteinlevelswerenotsignificant.Amongthemeasurements,serumsPLAsub2/subwastheonlymarkerthatshowedadose-dependentresponsetobothLPSandGEsupplementation.Thecurrentfindingsshowthatoralconsumptionofpolyphenolic-richGEsuppressesendotoxin-inducedsPLAsub2/subactivity.

机译：Thisstudyinvestigatedwhetherdietarysupplementationofpolyphenolics-richgrapeextract（GE）couldattenuateendotoxin-inducedserumsecretoryphospholipaseA <子> 2 （SPLA <子> 2 ）活性，amodulatorofinflammation.MaleSprague＃8211; Dawleyratswerefedacontroldietorthedietsupplementedwithpolyphenolic-richGE（100or300mg / kgdaily）for3wkpriortointraperitonealinjectionof3or15mg / kgLPS.AfluorometricassaywasusedtomeasureserumsPLA <子> 2 activityduringa5-dperiodbeforeandafterLPSinjection.Bodyweight，血细胞比容，andserumC-reactiveproteinlevelwerealsomeasured.AdministrationofLPSinducedarapidincreaseinsPLA <子> 2 活性，whichpeaked1to2dafterLPSinjectionandresolvedtonear-baselinevaluesondays4to5.Markeddeclinesinbodyweightandhematocrit，increasesinC-reactiveproteinlevels，andeffectsonhealthstatusalsooccurred.GEsupplementationsignificantlyattenuatedtheLPS-inducedincreaseinsPLA <子> 2 <血细胞比容的活性和下降，但其对体重减轻和C反应蛋白水平的影响并不显着。测量中，血清PLA _{2 是唯一显示剂量依赖性反应物的LPS和GE补充的标志物。目前的发现表明，富含多酚的GE的口服消费会抑制内毒素诱导的PLA _{2 活性。}}

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《Comparative Medicine》 |2012年第4期|共页
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Tsao Francis HC; Culver Bryan J; Pierre Joseph F; Shanmuganayagam Dhanansayan; Patten Calvin C; Meyer Keith C;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Effect of Prophylactic Supplementation with Grape Polyphenolics on Endotoxin-Induced Serum Secretory Phospholipase A(2) Activity in Rats [J] . Tsao Francis H. C., Culver Bryan J., Pierre Joseph F., Comparative Medicine . 2012,第4期

机译：预防性补充葡萄多酚对内毒素诱导的大鼠血清分泌磷脂酶A（2）活性的影响
2. Secretory phospholipase A2 activity in blood serum: The challenge to sense [J] . Alekseeva A. S., Korotaeva A. A., Samoilova E. V., Biochemical and Biophysical Research Communications . 2014,第1期

机译：分泌磷脂酶A2血清中的活性：感觉挑战
3. Secretory Phospholipase A2 activity in serum and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis [J] . SiroosB., BaloodM., ZahednasabH., Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2013,第1a2期

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4. Secretory phospholipase A2 and pulmonary surfactant interaction: a vicious circle during the development of acute respiratory distress syndrome. [C] . Acta pharmacologica sinica . 2002

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5. Serum amyloid A induces expression of secretory phospholipase A2 in vascular smooth muscle cells: A role in cholesterol trafficking. [D] . Sullivan, Christopher Paul. 2009

机译：血清淀粉样蛋白A诱导血管平滑肌细胞中分泌性磷脂酶A2的表达：在胆固醇运输中的作用。
6. Effect of Prophylactic Supplementation with Grape Polyphenolics on Endotoxin-Induced Serum Secretory Phospholipase A2 Activity in Rats [O] . Francis HC Tsao, Bryan J Culver, Joseph F Pierre, 2012

机译：预防性补充葡萄多酚对内毒素诱导的大鼠血清分泌磷脂酶A2活性的影响
7. Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A2 in young spontaneously hypertensive rats [O] . Levick, Scott, Loch, David, Rolfe, Barbara E., 2006

机译：IIA组分泌型磷脂酶A2抑制剂在年轻自发性高血压大鼠中的抗纤维化活性

Effect of Prophylactic Supplementation with Grape Polyphenolics on Endotoxin-Induced Serum Secretory Phospholipase A2 Activity in Rats

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