Expression of Maspin in the Early Pregnant Mouse Endometrium and Its Role during Embryonic Implantation

Huang Yan; Cai Lu-Wei; Yang Rong

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Expression of Maspin in the Early Pregnant Mouse Endometrium and Its Role during Embryonic Implantation

机译：Maspin在早孕小鼠子宫内膜中的表达及其在胚胎着床中的作用

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Maspin(serpinB5),atumor-suppressingmemberoftheserineproteaseinhibitorfamily,participatesincellmigration,adhesion,invasion,andapoptosis.Theseprocessesarealsocriticalforembryoimplantation,buttheroleofmaspininembryoimplantationremainspoorlyunderstood.Theaimofthepresentstudywastoinvestigatethespatiotemporalexpressionofmaspininearlypregnantmouseendometriumanditsroleinembryoimplantation.Real-timequantitativePCRanalysis,immunohistochemistry,andWesternblottingwereusedtodetectmRNAandproteinexpressionofmaspinintheendometriaofnonpregnantandearlypregnant(days0to7)mice.Onday3ofpregnancy,miceinthetreatedgroup(n=20)wereinjectedintheleftuterinehornwithantimaspinpolyclonalantibodyandintherighthornwithpurifiedrabbitIgG;controlmice(n=20)wereinjectedonlywithpurifiedrabbitIgGintherightuterinehorn.Implantedembryoswerecountedonpregnantday8.ThemRNAandproteinexpressionsofmaspinwerehigherintheendometriaofpregnantmicethannonpregnantmice;theselevelsgraduallyincreasedfromday1ofpregnancy,peakedonday5,andthendecreasedondays6and7.Themicetreatedwithantimaspinpolyclonalantibodygrouphadfarfewerimplantedembryosthandidthecontrolgroup.Takentogether,theseresultssuggestthatmaspin,atumorsuppressor,mayplayanimportantroleinembryoimplantation.

机译：的maspin（SERPINB5），atumor-suppressingmemberoftheserineproteaseinhibitorfamily，participatesincellmigration，粘附，侵入，andapoptosis.Theseprocessesarealsocriticalforembryoimplantation，buttheroleofmaspininembryoimplantationremainspoorlyunderstood.Theaimofthepresentstudywastoinvestigatethespatiotemporalexpressionofmaspininearlypregnantmouseendometriumanditsroleinembryoimplantation.Real-timequantitativePCRanalysis，免疫组织化学，andWesternblottingwereusedtodetectmRNAandproteinexpressionofmaspinintheendometriaofnonpregnantandearlypregnant（days0to7）mice.Onday3ofpregnancy，miceinthetreatedgroup（N = 20）wereinjectedintheleftuterinehornwithantimaspinpolyclonalantibodyandintherighthornwithpurifiedrabbitIgG; controlmice（N = 20 ）仅在右侧子宫角注射纯净的兔IgG。在怀孕的第8天，植入的胚胎的数量增加了。在怀孕的子宫内膜中，maspin的mRNA和蛋白的表达高于未怀孕的小鼠;从怀孕第5天起，该水平逐渐升高，从第5天开始逐渐增加。第6和第7天。用抗maspin多克隆抗体组治疗的小鼠被植入的胚芽少得多，而对照组则提示maspin，抑癌素可能起着重要的作用。

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《Comparative Medicine》 |2012年第3期|共页
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Huang Yan; Cai Lu-Wei; Yang Rong;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Expression of Maspin in the Early Pregnant Mouse Endometrium and Its Role during Embryonic Implantation. [J] . Huang Y, Cai LW, Yang R Comparative Medicine . 2012,第3期

机译：Maspin在早孕小鼠子宫内膜中的表达及其在胚胎着床过程中的作用。
2. Influences of treatment of early pregnant mares with the progestin altrenogest on embryonic development and gene expression in the endometrium and conceptus [J] . Willmann C., Budik S., Walter I., Theriogenology . 2011,第1期

机译：孕激素对孕早期母马的治疗对子宫内膜和子宫内膜胚胎发育和基因表达的影响
3. Ultrastructural studies on maternal-embryonic cell interaction during experimentally induced implantation of rat blastocysts to the endometrium of the mouse☆ [J] . Sumie Tachi, C. Tachi Developmental biology . 1979,第1期

机译：实验性将大鼠胚泡植入小鼠子宫内膜期间母体-胚胎细胞相互作用的超微结构研究☆
4. SLC- and NDUF-genes expression dynamics in pre-implantation embryonic development between bovine and mouse — A bioinformatics study [C] . Knocker Louisa, Zheng Rong Yang International Conference on BioMedical Engineering and Informatics . 2014

机译：SLC和NDUF基因在牛和小鼠植入前胚胎发育中的表达动态—生物信息学研究
5. Progesterone modulation of cytokine-directed matrix metalloproteinase expression in the human endometrium: A potential mechanism for maintaining tissue integrity during implantation and placental development. [D] . Keller, Nancy Renee. 2000

机译：孕激素调节人子宫内膜中细胞因子指导的基质金属蛋白酶表达：在植入和胎盘发育过程中维持组织完整性的潜在机制。
6. Testosterone Decreases the Number of Implanting Embryos Expression of Pinopode and L-selectin Ligand (MECA-79) in the Endometrium of Early Pregnant Rats [O] . Mohd Helmy Mokhtar, Nelli Giribabu, Naguib Salleh 2020

机译：睾丸激素可减少早孕大鼠子宫内膜的植入胚胎数量品指和L-选择素配体（MECA-79）的表达
7. Differential microRNA Expression in Porcine Endometrium Involved in Remodeling and Angiogenesis That Contributes to Embryonic Implantation [O] . Linjun Hong, Ruize Liu, Xiwu Qiao, 2019

机译：猪子宫内膜中的差异微小RNA表达参与重塑和血管生成，有助于胚胎植入
8. Prostate Specific Expression of Maspin in a Transgenic Mouse Model: Implications in Prostate Carcinogenesis [R] . Liu, Z. , Zhang, M. 2004

机译：maspin在转基因小鼠模型中的前列腺特异性表达：对前列腺癌发生的影响

Expression of Maspin in the Early Pregnant Mouse Endometrium and Its Role during Embryonic Implantation

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