Effects of Increased Dietary Cholesterol with Carbohydrate Restriction on Hepatic Lipid Metabolism in Guinea Pigs

deOgburn Ryan; Leite Jose O; Ratliff Joseph; Volek Jeff S; McGrane Mary M; Fernandez Maria Luz

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Effects of Increased Dietary Cholesterol with Carbohydrate Restriction on Hepatic Lipid Metabolism in Guinea Pigs

机译：限制饮食中增加胆固醇饮食对豚鼠肝脂质代谢的影响

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Excessivelipidaccumulationwithinhepatocytes,orhepaticsteatosis,isthepathognominicfeatureofnonalcoholicfattyliverdisease(NAFLD),adiseaseassociatedwithinsulinresistanceandobesity.Low-carbohydratediets(LCD)improvetheseconditionsandwereimplementedinthisstudytopotentiallyattenuatehepaticsteatosisinhypercholesterolemicguineapigs.Maleguineapigs(n=10pergroup)wererandomlyassignedtoconsumehighcholesterol(0.25g/100g)ineitheraLCDorahigh-carbohydratediet(HCD)for12wk.AscomparedwithHCD,plasmaLDLcholesterolwaslowerandplasmatriglycerideswerehigherinanimalsfedtheLCDdiet,withnodifferencesinplasmafreefattyacidsorglucose.Themostprominentfindingwasa40%increaseinliverweightinguineapigsfedtheLCDdietdespitenodifferencesinhepaticcholesterolortriglyceridesbetweentheLCDandtheHCDgroups.Regardlessofdiet,alllivershadseverehepaticsteatosisonhistologicexamination.Regressionanalysissuggestedthatliverweightwasindependentofbodyweightandlivermasswasindependentofhepaticlipidcontent.LCDlivershadmoreproliferatinghepatocytesthandidHCDlivers,suggestingthatinthecontextofcholesterol-inducedhepaticsteatosis,dietarycar-bohydraterestrictionenhanceslivercellproliferation.

机译：Excessivelipidaccumulationwithinhepatocytes，orhepaticsteatosis，isthepathognominicfeatureofnonalcoholicfattyliverdisease（NAFLD），adiseaseassociatedwithinsulinresistanceandobesity.Low-carbohydratediets（LCD）improvetheseconditionsandwereimplementedinthisstudytopotentiallyattenuatehepaticsteatosisinhypercholesterolemicguineapigs.Maleguineapigs（N = 10pergroup）wererandomlyassignedtoconsumehighcholesterol（0.25克/ 100克）ineitheraLCDorahigh-carbohydratediet（HCD）for12wk.AscomparedwithHCD，plasmaLDLcholesterolwaslowerandplasmatriglycerideswerehigherinanimalsfedtheLCDdiet，withnodifferencesinplasmafreefattyacidsorglucose.Themostprominentfindingwasa40％increaseinliverweightinguineapigsfedtheLCDdietdespitenodifferencesinhepaticcholesterolortriglyceridesbetweentheLCDandtheHCDgroups。不论饮食如何，所有肝脏均需进行肝病学病理学检查。回归分析表明，肝脏重量与肝脏重量无关，肝脏重量与肝脏脂质无关。LCD肝脏扩散的肝细胞更多。认为HCD肝脏在胆固醇诱发的肝硬变的背景下，饮食碳水化合物的限制可增强肝细胞的增殖。

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《Comparative Medicine》 |2012年第2期|共页
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deOgburn Ryan; Leite Jose O; Ratliff Joseph; Volek Jeff S; McGrane Mary M; Fernandez Maria Luz;
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Effects of increased dietary cholesterol with carbohydrate restriction on hepatic lipid metabolism in guinea pigs. [J] . Deogburn R., Leite J. O., Ratliff J., Comparative Medicine . 2012,第2期

机译：饮食中胆固醇水平升高和碳水化合物限制对豚鼠肝脂质代谢的影响。
2. Carbohydrate restriction and dietary cholesterol distinctly affect plasma lipids and lipoprotein subfractions in adult guinea pigs [J] . Torres-Gonzalez Moises, Leite Jose O., Volek Jeff S., The Journal of Nutritional Biochemistry . 2008,第12期

机译：碳水化合物的限制和饮食中的胆固醇明显影响成年豚鼠的血浆脂质和脂蛋白亚组分
3. Hypolipidemic mechanisms of pectin and psyllium in guinea pigs fed high fat-sucrose diets: alterations on hepatic cholesterol metabolism. [J] . Vergara-Jimenez M, Conde K, Erickson SK, Journal of Lipid Research . 1998,第7期

机译：饲喂高脂肪蔗糖日粮的豚鼠的果胶和车前子的降血脂机制：肝胆固醇代谢的改变。
4. Differences in triglyceride metabolism in guinea pigs and rats fed high-fat diets containing 0.1 cholesterol and 10 lard [C] . Guo Peng, Yang Runmei, Gao Nannan 2011 IEEE/ICME International Conference on Complex Medical Engineering . 2011

机译：高脂饮食含0.1％胆固醇和10％猪油的豚鼠和大鼠的甘油三酸酯代谢差异
5. Effects of dietary cholesterol and carbohydrate restriction on plasma and hepatic lipid metabolism, atherosclerosis and inflammation in guinea pigs [D] . Torres-Gonzalez, Moises 2007

机译：饮食中胆固醇和碳水化合物的限制对豚鼠血浆和肝脂质代谢，动脉粥样硬化和炎症的影响
6. Effects of Increased Dietary Cholesterol with Carbohydrate Restriction on Hepatic Lipid Metabolism in Guinea Pigs [O] . Ryan deOgburn, Jose O Leite, Joseph Ratliff, 2012

机译：限制饮食中增加胆固醇含量对豚鼠肝脂质代谢的影响
7. Regulation of hepatic LDL metabolism in the guinea pig by dietary fat and cholesterol. [O] . E C Lin, M L Fernandez, M A Tosca, 1994

机译：膳食脂肪和胆固醇调节豚鼠中豚鼠的肝脏LDL代谢。

Effects of Increased Dietary Cholesterol with Carbohydrate Restriction on Hepatic Lipid Metabolism in Guinea Pigs

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