Development of a Rabbit Pleural Cancer Model by Using VX2 Tumors

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Development of a Rabbit Pleural Cancer Model by Using VX2 Tumors

机译：使用VX2肿瘤开发兔胸膜癌模型。

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Primaryandsecondarypleuralcancerremainsanimportantclinicalproblem,withresearchprogresslimitedbythelackofasuitablemoderate-tolarge-sized(3to4kg)animalmodelofpleuralcancer.Manypotentialpleura-basedimagingandtreatmentmodalitiescannotbeinvestigatedsufficientlybyusingcurrentlyavailablesmallmurineanimalmodelsbecausetheirpleuralspaceisnotcomparabletothatofhumansandthereforedoesnotallowfortheuseofstandardthoracoscopictechniques.Herewedescribethedevelopmentofareproduciblemodelofpleuralmalignancyinmoderate-sizedimmunocompetentrabbits.Underthoracoscopicguidance,9#8211;15×10supxmlns="http://pub2web.metastore.ingenta.coms/"6/supVX2carcinomacellswereinoculatedintothepluralspaceof3to4kgNewZealandwhiterabbitsthathadundergonegentlepleuralabrasion.Malignanttumorinvolvementdevelopedonthevisceralandparietalpleuralsurfacesinanaverageof2to4wk.Thisnovelpleuraltumormodelinductionmethodlikelywillfacilitateabroadrangeofinvestigationsofpleuralcancerdiagnosticsandtherapeutics.

机译：Primaryandsecondarypleuralcancerremainsanimportantclinicalproblem，withresearchprogresslimitedbythelackofasuitablemoderate-tolarge尺寸（3to4kg）animalmodelofpleuralcancer.Manypotentialpleura-basedimagingandtreatmentmodalitiescannotbeinvestigatedsufficientlybyusingcurrentlyavailablesmallmurineanimalmodelsbecausetheirpleuralspaceisnotcomparabletothatofhumansandthereforedoesnotallowfortheuseofstandardthoracoscopictechniques.Herewedescribethedevelopmentofareproduciblemodelofpleuralmalignancyinmoderate-sizedimmunocompetentrabbits.Underthoracoscopicguidance，9＃8211; 15×10 6 将VX2癌细胞接种到3至4公斤的新西兰空白兔子中，这些兔子曾经历了剧烈的胸膜擦伤。在内脏顶叶胸膜上发展出的恶性肿瘤累及率平均为2到4周，这可能是一种可行的方法。

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《Comparative Medicine》 |2008年第3期|共页
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中图分类畜牧、动物医学、狩猎、蚕、蜂;
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1. Development of a Rabbit Pleural Cancer Model by Using VX2 Tumors. [J] . Kreuter K.A., El-Abbadi N., Shbeeb A., Comparative Medicine . 2008,第3期

机译：通过使用VX2肿瘤开发兔胸膜癌模型。
2. Relationships among tumor burden, tumor size, and the changing concentrations of fibrin degradation products and fibrinolytic factors in the pleural effusions of rabbits with VX2 lung tumors. [J] . Hatton MW, Southward SM, Ross BL, The Journal of laboratory and clinical medicine . 2006,第1期

机译：VX2肺肿瘤兔胸腔积液中肿瘤负荷，肿瘤大小以及纤维蛋白降解产物和纤溶因子浓度变化之间的关系。
3. Ultrasonic Cavitation Ameliorates Antitumor Efficacy of Residual Cancer After Incomplete Radiofrequency Ablation in Rabbit VX2 Liver Tumor Model [J] . Shi-yan Li, Pin-tong Huang, Yong Fang, Translational Oncology . 2019,第8期

机译：超声空化改善不完全射频消融后兔VX2肝肿瘤模型中残留癌的抗肿瘤功效
4. Efficacy of MR-guided Focused Ultrasound Thermal Ablation of Rabbit VX2 Tumors [C] . Xiangtao Yin, Yongzhi Zhang, Karen Tam, International Symposium on Therapeutic Ultrasound . 2006

机译：MR引导的聚焦超声热消融兔VX2肿瘤的功效
5. Comparing gene expression profiles of cell culture models with profiles of tumor xenografts and patient tumors: Implications for lung and breast cancers. [D] . Creighton, Chad J. 2006

机译：将细胞培养模型的基因表达谱与异种移植瘤和患者肿瘤谱进行比较：对肺癌和乳腺癌的影响。
6. Development of a Rabbit Pleural Cancer Model by Using VX2 Tumors [O] . Kelly A. Kreuter, Naglaa El-Abbadi, Alia Shbeeb, 2008

机译：使用VX2肿瘤开发兔胸膜癌模型。
7. Development of a VX2 Pancreatic Cancer Model in Rabbits: A Pilot Study [O] . Aaron C. Eifler, Robert J. Lewandowski, Sumeet Virmani, 2009

机译：兔VX2胰腺癌模型的发展：试验研究

Development of a Rabbit Pleural Cancer Model by Using VX2 Tumors

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