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首页> 外文期刊>Comparative Medicine >Development of a Rabbit Pleural Cancer Model by Using VX2 Tumors.
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Development of a Rabbit Pleural Cancer Model by Using VX2 Tumors.

机译：通过使用VX2肿瘤开发兔胸膜癌模型。

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Primary and secondary pleural cancer remains an important clinical problem, with research progress limited by the lack of a suitable moderate- to large-sized (3 to 4 kg) animal model of pleural cancer. Many potential pleura-based imaging and treatment modalities cannot be investigated sufficiently by using currently available small murine animal models because their pleural space is not comparable to that of humans and therefore does not allow for the use of standard thoracoscopic techniques. Here we describe the development of a reproducible model of pleural malignancy in moderate-sized immunocompetent rabbits. Under thoracoscopic guidance, 9-15 x 10e VX2 carcinoma cells were inoculated into the plural space of 3 to 4 kg New Zealand white rabbits that had undergone gentle pleural abrasion. Malignant tumor involvement developed on the visceral and parietal pleural surfaces in an average of 2 to 4 wk. This novel pleural tumor model induction method likely will facilitate a broad range of investigations of pleural cancer diagnostics and therapeutics.
机译：原发性和继发性胸膜癌仍然是一个重要的临床问题，其研究进展受到缺乏合适的中大型（3-4公斤）胸膜癌动物模型的限制。许多潜在的基于胸膜的成像和治疗方式无法通过使用当前可用的小型鼠类动物模型进行充分研究，因为它们的胸膜空间与人类的胸膜空间不可比，因此不允许使用标准的胸腔镜技术。在这里，我们描述了中等免疫能力的兔胸膜恶性肿瘤可复制模型的发展。在胸腔镜引导下，将9-15 x 10e VX2癌细胞接种到3至4公斤新西兰白兔的多个空间中，这些兔经历了轻度的胸膜磨损。内脏和壁层胸膜表面平均2到4周出现恶性肿瘤累及。这种新颖的胸膜肿瘤模型诱导方法可能会促进胸膜癌诊断和治疗方法的广泛研究。

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