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首页> 外文期刊>Comparative Medicine >Cyclosporine-Induced Gingival Overgrowth in New Zealand White Rabbits (Oryctolagus cuniculus)
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Cyclosporine-Induced Gingival Overgrowth in New Zealand White Rabbits (Oryctolagus cuniculus)

机译：环孢素诱导的新西兰白兔牙龈过度生长（Oryctolagus cuniculus）

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AhighincidenceofgingivalovergrowthoccurredinagroupofNewZealandWhiterabbitsreceivingdailycyclosporine(15mg/kgIM)whileonaretinoblastomastudy.Overthecourseof2mo,rabbitspresentedwithclinicalsignsofptyalism(4of18rabbits),inappetence(3of18),orboth(3of18);facialdermatitisanderythemaoccurredsecondarytoptyalism.Reducingthedoseofcyclosporineto10mg/kgledtocompleteresolutionofclinicalsignsinallbut2rabbits,whichthenreceivedazithromycin(62.5mgPOoncedailyfor7d),acommontreatmentforcyclosporine-inducedgingivalovergrowthinotherspecies.Afterdosereductionandazithromycintreatment,clinicalsignsresolvedanddidnotreoccurfortheremainderofthestudy.Fourteenrabbitswerenecropsiedattheendofthestudy,andgingivalwidthwasmeasured.Althoughsomerabbitswereclinicallynormal,thegingivainallrabbitswasgrosslythickened.Rabbitsoncyclosporinehadmolargingivathatwassignificantlythicker(4.8mm)thancontrols(2.5mm)nottreatedwithcyclosporine.Histologicanalysisofthegingivarevealedmildtomoderategingivalepithelialhyperplasia,hyperkeratosis,andmildinflammation.Gingivalovergrowthisaknownsideeffectofcyclosporineadministrationinotherspeciesbut,toourknowledge,thisreportisthefirstdescriptionoftheconditioninrabbits.Becauserabbitsfrequentlyareusedinstudiesthatinvolvesystemiccyclosporineadministration,cliniciansareadvisedtoincludethispossibilityintheirdifferentiallistforcasesinvolvinghypersalivation,facialdermatitis,orinappetenceinrabbits.
机译：AhighincidenceofgingivalovergrowthoccurredinagroupofNewZealandWhiterabbitsreceivingdailycyclosporine（15毫克/ kgIM）whileonaretinoblastomastudy.Overthecourseof2mo，rabbitspresentedwithclinicalsignsofptyalism（4of18rabbits），食欲不振（3of18），orboth（3of18）; facialdermatitisanderythemaoccurredsecondarytoptyalism.Reducingthedoseofcyclosporineto10mg / kgledtocompleteresolutionofclinicalsignsinallbut2rabbits，whichthenreceivedazithromycin（62.5mgPOoncedailyfor7d），acommontreatmentforcyclosporine-inducedgingivalovergrowthinotherspecies.Afterdosereductionandazithromycintreatment，clinicalsignsresolvedanddidnotreoccurfortheremainderofthestudy.Fourteenrabbitswerenecropsiedattheendofthestudy，andgingivalwidthwasmeasured.Althoughsomerabbitswereclinicallynormal兔子的环孢菌素粗大地厚了（4.8毫米），比未用环孢菌素处理的对照（2.5毫米）大了。牙龈增生在另一种物种上已广为人知，这是环孢菌素管理的另一种副作用，但据我们所知，本报告是对这种情况的首次描述。由于阿拉伯人经常使用这种研究方法，涉及系统性环孢菌素的治疗，因此在临床上，研究人员认为这种情况可能会导致这种情况。

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