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首页> 外文期刊>Comparative Medicine >Cyclosporine-induced gingival overgrowth in New Zealand White rabbits (Oryctolagus cuniculus)
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Cyclosporine-induced gingival overgrowth in New Zealand White rabbits (Oryctolagus cuniculus)

机译：环孢菌素引起的新西兰白兔齿龈过度生长（Oryctolagus cuniculus）

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摘要

A high incidence of gingival overgrowth occurred in a group of New Zealand White rabbits receiving daily cyclosporine (15 mg/kg IM) while on a retinoblastoma study. Over the course of 2 mo, rabbits presented with clinical signs of ptyalism (4 of 18 rabbits), inappetence (3 of 18), or both (3 of 18); facial dermatitis and erythema occurred secondary to ptyalism. Reducing the dose of cyclosporine to 10 mg/kg led to complete resolution of clinical signs in all but 2 rabbits, which then received azithromycin (62.5 mg PO once daily for 7 d), a common treatment for cyclosporine-induced gingival overgrowth in other species. After dose reduction and azithromycin treatment, clinical signs resolved and did not reoccur for the remainder of the study. Fourteen rabbits were necropsied at the end of the study, and gingival width was measured. Although some rabbits were clinically normal, the gingiva in all rabbits was grossly thickened. Rabbits on cyclosporine had molar gingiva that was significantly thicker (4.8 mm) than controls (2.5 mm) not treated with cyclosporine. Histologic analysis of the gingiva revealed mild to moderate gingival epithelial hyperplasia, hyperkeratosis, and mild inflammation. Gingival overgrowth is a known side effect of cyclosporine administration in other species but, to our knowledge, this report is the first description of the condition in rabbits. Because rabbits frequently are used in studies that involve systemic cyclosporine administration, clinicians are advised to include this possibility in their differential list for cases involving hypersalivation, facial dermatitis, or inappetence in rabbits.
机译：在视网膜母细胞瘤研究中，每天接受环孢素（15 mg / kg IM）的一组新西兰白兔发生了牙龈过度生长的高发生率。在2 mo的过程中，兔子表现出有精神分裂症的临床征象（18只兔子中的4只），食欲不振（18只兔子中的3只）或两者兼有（18只兔子中的3只）;面部皮肤炎和红斑继发于tytalism。将环孢霉素的剂量降低至10 mg / kg可以完全缓解除2只兔子以外的所有其他动物的临床体征，然后再接受阿奇霉素（62.5 mg口服，每天一次，连续7天），这是其他物种中环孢素引起的牙龈过度生长的常见治疗方法。减量和阿奇霉素治疗后，临床体征消失，在其余研究中未再出现。在研究结束时对14只兔子进行尸检，并测量牙龈宽度。尽管某些兔子临床上正常，但所有兔子的牙龈都明显增厚。接受环孢素的兔子的牙龈磨牙比未用环孢素治疗的对照（2.5 mm）明显厚（4.8 mm）。牙龈的组织学分析显示轻度至中度的牙龈上皮增生，角化过度和轻度炎症。牙龈过度生长是在其他物种中使用环孢霉素的已知副作用，但是据我们所知，本报告是对兔子状况的首次描述。由于兔子经常用于涉及全身性环孢素给药的研究中，因此建议临床医生将这种可能性纳入涉及唾液分泌过多，面部皮肤炎或兔子食欲不振的病例的差异清单中。

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