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Treatment of Giardiasis in Common Marmosets (Callithrix jacchus) with Tinidazole

机译:替硝唑治疗普通Mar猴的贾第鞭毛虫病

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Giardiaintestinalisisacommonprotozoanparasitethatcaninfectmanylaboratoryanimalprimates,althoughitsroleasacontributortotheinductionofgastrointestinaldiseaseremainsunclear.ThisstudysoughttoinvestigatetheprevalenceofGiardiainacolonyofcommonmarmosetsbyusingaGiardiaantigen-captureassayandtoaddressthepossibleeradicationofthisinfectionbyusingtinidazole,anantiprotozoalsimilartometronidazolebutrequiringfewerdoses.Among31colonymarmosets,13(42%)werepositiveforGiardia.Twodosesoforaltinidazoleeliminatedtheinfectioninallanimals.Repeattestingofthe13Giardia-positivemonkeys1ylatershowedthat11remainednegativeandthattreatedanimalshadasignificantincreaseinweightat1y.Giardiaantigeniscommonincommonmarmosetfeces,andtreatmentusingoraltinidazoleispossibleandhighlyeffective.
机译:Giardiaintestinalisisacommonprotozoanparasitethatcaninfectmanylaboratoryanimalprimates,althoughitsroleasacontributortotheinductionofgastrointestinaldiseaseremainsunclear.ThisstudysoughttoinvestigatetheprevalenceofGiardiainacolonyofcommonmarmosetsbyusingaGiardiaantigen-captureassayandtoaddressthepossibleeradicationofthisinfectionbyusingtinidazole,anantiprotozoalsimilartometronidazolebutrequiringfewerdoses.Among31colonymarmosets,13(42%)werepositiveforGiardia.Twodosesoforaltinidazoleeliminatedtheinfectioninallanimals.Repeattestingofthe13Giardia-positivemonkeys1ylatershowedthat11remainednegativeandthattreatedanimalshadasignificantincreaseinweightat1y.Giardiaantigeniscommonincommonmarmosetfeces,andtreatmentusingoraltinidazoleispossibleandhighlyeffective。

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